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Folate

Known as: 2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid, Vitamin B-11, folates 
A cofactor for 1-carbon transfer involved with DNA synthesis.
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Purpose of ReviewResearch has evaluated the potential impact of folate on cancer risk with conflicting findings. Studies have… Expand
Review
2017
Review
2017
Moderate hyperhomocysteinemia‐induced low folate status is an independent risk factor for cardiovascular disease, dementia, and… Expand
Highly Cited
2006
Highly Cited
2006
Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic processes. While folates are… Expand
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Highly Cited
2005
Highly Cited
2005
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety of cancers. The current… Expand
Highly Cited
2004
Highly Cited
2004
  • H. Yoo, T. Park
  • Journal of controlled release : official journal…
  • 2004
  • Corpus ID: 7856340
Biodegradable polymeric micelles, self-assembled from a di-block copolymer of poly(D,L-lactic-co-glycolic acid) (PLGA) and poly… Expand
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Review
2003
Review
2003
Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine -- a cytotoxic sulfur… Expand
Highly Cited
2002
Highly Cited
2002
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… Expand
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Review
2000
Review
2000
The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of ovarian carcinomas. Two general… Expand
Highly Cited
1997
Highly Cited
1997
Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell) and chromosome breaks. The likely… Expand
Highly Cited
1995
Highly Cited
1995
  • R. Lee, P. Low
  • Biochimica et biophysica acta
  • 1995
  • Corpus ID: 38950593
Receptors for the vitamin folic acid are frequently overexpressed on epithelial cancer cells. To examine whether this… Expand