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Folate

Known as: 2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid, Vitamin B-11, folates 
A cofactor for 1-carbon transfer involved with DNA synthesis.
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
Summary The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action… Expand
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Highly Cited
2008
Highly Cited
2008
Tetrahydrofolate (THF) polyglutamates are a family of cofactors that carry and chemically activate one-carbon units for… Expand
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Highly Cited
2006
Highly Cited
2006
Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic processes. While folates are… Expand
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Highly Cited
2005
Highly Cited
2005
The folate receptor (FR) is a valuable therapeutic target that is highly expressed on a variety of cancers. The current… Expand
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Highly Cited
2004
Highly Cited
2004
Biodegradable polymeric micelles, self-assembled from a di-block copolymer of poly(D,L-lactic-co-glycolic acid) (PLGA) and poly… Expand
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Review
2003
Review
2003
Folate is a cofactor in one-carbon metabolism, during which it promotes the remethylation of homocysteine -- a cytotoxic sulfur… Expand
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Highly Cited
2002
Highly Cited
2002
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… Expand
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Review
2000
Review
2000
The folate receptor is a highly selective tumor marker overexpressed in greater than 90% of ovarian carcinomas. Two general… Expand
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Highly Cited
1997
Highly Cited
1997
Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell) and chromosome breaks. The likely… Expand
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Highly Cited
1991
Highly Cited
1991
We describe the isolation of a complementary DNA (cDNA) sequence encoding the ovarian cancer-associated antigen recognized by… Expand
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