Folate

Known as: 2-[4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoyl]aminopentanedioic acid, Vitamin B-11, folates 
A cofactor for 1-carbon transfer involved with DNA synthesis.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1957-2018
010020019572017

Papers overview

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Review
2016
Review
2016
Moderately elevated plasma total homocysteine (tHcy) is a strong modifiable risk factor for vascular dementia and Alzheimer's… (More)
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Highly Cited
2006
Highly Cited
2006
Folates are essential nutrients that are required for one-carbon biosynthetic and epigenetic processes. While folates are… (More)
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Highly Cited
2006
Highly Cited
2006
Folate is critical for nucleotide synthesis and methylation reactions and has been associated with a number of health benefits… (More)
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Highly Cited
2004
Highly Cited
2004
Folate plays an important role in DNA methylation, synthesis, and repair; intake has been associated with breast cancer. The… (More)
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Highly Cited
2002
Highly Cited
2002
DNA methylation, an essential epigenetic feature of DNA that modulates gene expression and genomic integrity, is catalyzed by… (More)
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Highly Cited
1999
Highly Cited
1999
Elevated plasma homocysteine levels are associated with increased risk for cardiovascular disease and neural tube defects in… (More)
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Highly Cited
1997
Highly Cited
1997
Folate deficiency causes massive incorporation of uracil into human DNA (4 million per cell) and chromosome breaks. The likely… (More)
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Highly Cited
1997
Highly Cited
1997
Folate is essential for the de novo biosynthesis of purines and thymidylate, and is an important mediator in the transfer of… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND The dietary reference values for folate, as for other nutrients, are targeted to the general and supposedly normal… (More)
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Highly Cited
1986
Highly Cited
1986
Cultured monkey kidney cells are shown to possess a cell-surface receptor that binds 5-methyltetrahydro[3',5',7,9-3H4]folic acid… (More)
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