Corpus ID: 10350380

Transport of folate compounds in L1210 cells: kinetic evidence that folate influx proceeds via the high-affinity transport system for 5-methyltetrahydrofolate and methotrexate.

@article{Henderson1986TransportOF,
  title={Transport of folate compounds in L1210 cells: kinetic evidence that folate influx proceeds via the high-affinity transport system for 5-methyltetrahydrofolate and methotrexate.},
  author={Gary B. Henderson and Mavanur R. Suresh and K. S. Vitols and Frank M. Huennekens},
  journal={Cancer research},
  year={1986},
  volume={46 4 Pt 1},
  pages={
          1639-43
        }
}
  • Gary B. Henderson, Mavanur R. Suresh, +1 author Frank M. Huennekens
  • Published in Cancer research 1986
  • Medicine
  • Folate is transported into L1210 mouse leukemia cells by the same system that mediates the uptake of methotrexate and reduced folate compounds. This conclusion is supported by the following observations: (a) methotrexate competitively inhibits the influx of folate and the Ki is comparable to the Kt for methotrexate influx; (b) the profile for inhibition of folate influx by methotrexate is monophasic and complete inhibition is achieved at high concentrations of the competitor; (c) folate… CONTINUE READING

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