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Flucytosine

Known as: 5-Fluorocystosine, Fluorcytosine, 2(1H)-Pyrimidinone, 4-amino-5-fluoro- 
A pyrimidine compound and a fluorinated cytosine analog exhibiting antifungal activity. After penetration into the fungal cells, flucytosine is… 
National Institutes of Health

Related topics

Related topics

25 relations
5-Fluorocytosine:MCnc:Pt:XXX:Qn5-fluorocytosine:Mass:Point in time:Dose med or substance:QuantitativeAIDS-Related Opportunistic InfectionsAspergillosis

Narrower (1)

Ancobon

Broader (5)

Antifungal AgentsAntimetaboliteshalocarbon compoundhalopyrimidine

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Singlet excited-state dynamics of 5-fluorocytosine and Cytosine: an experimental and computational study.
The photophysics of singlet excited 5-fluorocytosine (5FC) was studied in steady-state and time-resolved experiments and… 
Highly Cited
2002
Highly Cited
2002
Intratumoral 5-fluorouracil produced by cytosine deaminase/5-fluorocytosine gene therapy is effective for experimental human glioblastomas.
5-Fluorouracil (5-FU) is a potent antimetabolite used for chemotherapy of gastrointestinal (GI), breast, and head and neck… 
Highly Cited
2002
Highly Cited
2002
Efficacy and toxicity of replication-competent adenovirus-mediated double suicide gene therapy in combination with radiation therapy in an orthotopic mouse prostate cancer model.
Highly Cited
1997
Highly Cited
1997
In vivo selective gene expression and therapy mediated by adenoviral vectors for human carcinoembryonic antigen-producing gastric carcinoma.
Previously, we reported that adenoviral vectors carrying the carcinoembryonic antigen (CEA) promoter sequences to direct the… 
Highly Cited
1996
Highly Cited
1996
Monitoring gene therapy with cytosine deaminase: in vitro studies using tritiated-5-fluorocytosine.
UNLABELLED Genetically modified mammalian cells that express the cytosine deaminase (CD) gene are able to convert the nontoxic… 
Highly Cited
1996
Highly Cited
1996
In vivo replication-deficient adenovirus vector-mediated transduction of the cytosine deaminase gene sensitizes glioma cells to 5-fluorocytosine.
Viral vector-mediated transfer of chemosensitization genes represents a promising new approach to the treatment of cancer… 
Highly Cited
1990
Highly Cited
1990
Candida albicans in patients with the acquired immunodeficiency syndrome: absence of a novel of hypervirulent strain.
To determine whether Candida albicans in patients with AIDS represents a unique strain, C. albicans isolated from 24 patients… 
Highly Cited
1976
Highly Cited
1976
Pars plana vitrectomy in the management of endogenous Candida endophthalmitis.
Highly Cited
1973
Highly Cited
1973
Pharmacokinetic studies on the oral antimycotic agent 5-fluorocytosine in individuals with normal and impaired kidney function.
Pharmacokinetic studies were performed on the systemic antimycotic agent 5-fluorocytosine (5-FC) by giving 2 g orally to 10… 
Highly Cited
1972
Highly Cited
1972
Hematogenous Candida endophthalmitis--a complication of candidemia.
Abstract Six patients with candidemia and candida endophthalmitis had received systemic antibiotics and had prolonged indwelling… 
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