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A rare genotype of Cryptococcus gattii caused the cryptococcosis outbreak on Vancouver Island (British Columbia, Canada).
TLDR
The emergence of this usually tropical pathogen on Vancouver Island highlights the changing distribution of this genotype and emphasizes the importance of an ongoing collaborative effort to monitor the global epidemiology of this yeast.
Cryptococcal Yeast Cells Invade the Central Nervous System via Transcellular Penetration of the Blood-Brain Barrier
TLDR
The findings indicate that C. neoformans cells invade the central nervous system by transcellular crossing of the endothelium of the BBB.
Epidemiologic differences between the two varieties of Cryptococcus neoformans.
This report of the worldwide distribution of two varieties of Cryptococcus neoformans was drawn from data on 628 clinical isolates and from data on 97 additional isolates from other laboratories.
Cryptococcus neoformans and Cryptococcus gattii, the etiologic agents of cryptococcosis.
TLDR
Topics focused on in this article include species description, pathogenesis, life cycle, capsule, and stress response, which serve to highlight the specializations in virulence that have occurred in this unique encapsulated melanin-forming yeast that causes global deaths estimated at more than 600,000 annually.
The Developmentally Regulated alb1 Gene ofAspergillus fumigatus: Its Role in Modulation of Conidial Morphology and Virulence
TLDR
The results suggest that disruption of alb1 causes pleiotropic effects on conidial morphology and fungal virulence.
Genetic association of mating types and virulence in Cryptococcus neoformans
TLDR
Testing for virulence in mice suggested the genetic association of virulence with mating type in this human fungal pathogen alpha type was clearly more virulent than a type.
A Developmentally Regulated Gene Cluster Involved in Conidial Pigment Biosynthesis in Aspergillus fumigatus
TLDR
The presence of abr1, abr2, and ayg1 in addition to alb1, arp1, and arp2 suggests that conidial pigment biosynthesis in A. fumigatus is more complex than the known DHN-melanin pathway.
Cryptococcus neoformans Overcomes Stress of Azole Drugs by Formation of Disomy in Specific Multiple Chromosomes
TLDR
Comparison genome hybridization and quantitative real-time PCR is used to show that C. neoformans adapts to high concentrations of FLC by duplication of multiple chromosomes, which may play an important role in FLC therapy failure of cryptococcosis leading to relapse during azole maintenance therapy.
Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C)
TLDR
A simple new agar medium containing L-canavanine, glycine, and bromthymol blue was found to give a clearer and more accurate distinction between serotype A or D and serotype B or C (C. neoformans var. gattii) than creatinine-dextrose-bromthyl blue or glycine-cycloheximide-phenol red media.
Isolation of the URA5 gene from Cryptococcus neoformans var. neoformans and its use as a selective marker for transformation
TLDR
A cDNA encoding Cryptococcus neoformans orotidine monophosphate pyrophosphorylase (OMPPase) has been isolated by complementation of the cognate Escherichia coli pyrE mutant by using electroporation for the introduction of plasmid DNA containing the URA5 gene.
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