Farnesyl Transferase Inhibitor

Known as: Farnesyl Transferase Inhibitors, Farnesyltransferase Inhibitors, FTI 
Any substance that inhibits protein farnesyltransferase, an enzyme that catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a… (More)
National Institutes of Health

Papers overview

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Review
2006
Review
2006
Three mammalian nuclear lamin proteins, lamin B(1), lamin B(2) and the lamin A precursor, prelamin A, undergo canonical… (More)
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Highly Cited
2005
Highly Cited
2005
Lonafarnib (SCH66336) is a farnesyl transferase inhibitor (FTI) that inhibits the post-translational lipid modification of H-Ras… (More)
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Highly Cited
2003
Highly Cited
2003
We investigated the clinical activity of the farnesyl transferase inhibitor R115777 in 22 patients with chronic myelogenous… (More)
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Highly Cited
2002
Highly Cited
2002
The development of chronic myeloid leukemia (CML) is dependent on the deregulated tyrosine kinase of the oncoprotein BCR-ABL… (More)
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Highly Cited
2001
Highly Cited
2001
Farnesyl:protein transferase (FPTase) inhibitors (FTIs) were originally developed as potential anticancer agents targeting the… (More)
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Review
2001
Review
2001
Activating oncogenic mutations of the RAS gene are common in cancer, occurring in 30% of solid tumours in adults. Inhibitors of… (More)
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Highly Cited
2000
Highly Cited
2000
Human tumor cell lines that are sensitive to the effects of farnesyl transferase inhibitors accumulate in G(2) --> M (except for… (More)
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Highly Cited
1998
Highly Cited
1998
An important class of cellular proteins, which includes members of the p21ras family, undergoes posttranslational farnesylation… (More)
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Highly Cited
1997
Highly Cited
1997
Farnesyl transferase inhibitors (FTIs) are a novel class of antitumor drugs that block the oncogenic activity of Ras. Because… (More)
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Highly Cited
1995
Highly Cited
1995
ras oncogenes are present in several types of cancers but are most frequently described in colon and pancreatic carcinomas… (More)
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