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SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern
Together, these papers show a balance among mutations that enhance stability, those that increase binding to the human receptor ACE2, and those that confer resistance to neutralizing antibodies, as revealed by mass spectrometry and structural studies.
Efficient technique for screening drugs for activity against Trypanosoma cruzi using parasites expressing beta-galactosidase
- F. Buckner, C. Verlinde, A. L. La Flamme, W. V. Van Voorhis
- BiologyAntimicrobial agents and chemotherapy
- 1 November 1996
An assay with beta-galactosidase-expressing T. cruzi greatly simplifies screening drugs for selective anti-T.
SARS-CoV-2 immune evasion by variant B.1.427/B.1.429
Data show that Abs directed to the NTD impose a selection pressure driving SARS-CoV-2 viral evolution through conventional and unconventional escape mechanisms and warrant closer monitoring of signal peptide variants and their involvement in immune evasion.
Treponema pallidum Major Sheath Protein Homologue Tpr K Is a Target of Opsonic Antibody and the Protective Immune Response
- A. Centurión-Lara, C. Castro, S. Lukehart
- BiologyThe Journal of experimental medicine
- 15 February 1999
Antibodies directed to purified recombinant variable domain of Tpr K can opsonize T. pallidum, Nichols strain, for phagocytosis, supporting the hypothesis that this portion of the protein is exposed at the surface of the treponeme.
Chemical genetics of Plasmodium falciparum
A phenotypic forward chemical genetic approach to discover new antimalarial chemotypes and structures and biological activity of the entire library are disclosed, many of which showed potent in vitro activity against drug-resistant P. falciparum strains.
Heterologous expression of proteins from Plasmodium falciparum: results from 1000 genes.
Opsonic potential, protective capacity, and sequence conservation of the Treponema pallidum subspecies pallidum Tp92.
- C. Cameron, S. Lukehart, C. Castro, B. Molini, C. Godornes, W. V. Van Voorhis
- BiologyThe Journal of infectious diseases
- 1 April 2000
It is demonstrated that Tp92 is an invariant, immunoprotective antigen that may be present on the surface of T. pallidum and may represent a potential vaccine candidate for syphilis.
Stabilizing Additives Added during Cell Lysis Aid in the Solubilization of Recombinant Proteins
- D. Leibly, T. N. Nguyen, Louis T. Kao, S. Hewitt, L. Barrett, W. V. Van Voorhis
- BiologyPloS one
- 20 December 2012
It is hypothesized that small molecules added during the cell lysis stage can yield soluble protein from insoluble protein previously screened without additives or ligands, and this protocol allowed us to recover about a third of seemingly insoluble proteins for crystallography and structure determination.
Molecular basis of immune evasion by the delta and kappa SARS-CoV-2 variants
A previously uncharacterized class of N-terminal domain-directed human neutralizing monoclonal antibodies cross-reacting with several variants of concern is described, revealing a possible target for vaccine development.
Review: nomenclature and biologic significance of cytokines involved in inflammation and the host immune response.
This is a brief review of 42 cytokines and interleukins that are involved inflammatory and immune responses. The cytokines are listed in tables organized as hematopoietic growth factors, interferons,…