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Farnesyl Pyrophosphate Synthetase, human

Known as: FPP Synthetase, (2E,6E)-Farnesyl Diphosphate Synthase, Farnesyl Diphosphate Synthase 
Farnesyl pyrophosphate synthase (419 aa, ~48 kDa) is encoded by the human FDPS gene. This protein plays a role in the synthesis of geranyl… 
National Institutes of Health

Related topics

Related topics

5 relations
Enzyme GeneFDPS geneLipid MetabolismTerpenoid Biosynthesis Pathway

Broader (1)

Geranyltranstransferase

Papers overview

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Highly Cited
2015
Highly Cited
2015
Engineering Methylobacterium extorquens for de novo synthesis of the sesquiterpenoid α-humulene from methanol.
Highly Cited
2009
Highly Cited
2009
Lipophilic bisphosphonates as dual farnesyl/geranylgeranyl diphosphate synthase inhibitors: an X-ray and NMR investigation.
Considerable effort has focused on the development of selective protein farnesyl transferase (FTase) and protein geranylgeranyl… 
Highly Cited
2004
Highly Cited
2004
Mono and diterpene production in Escherichia coli
Mono‐ and diterpenoids are of great industrial and medical value as specialty chemicals and pharmaceuticals. Production of these… 
Highly Cited
1998
Highly Cited
1998
Synergistic activation of transcription by nuclear factor Y and sterol regulatory element binding protein.
Highly Cited
1997
Highly Cited
1997
Conversion from Archaeal Geranylgeranyl Diphosphate Synthase to Farnesyl Diphosphate Synthase
Farnesyl diphosphate (FPP) and geranylgeranyl diphosphate (GGPP) are precursors for a variety of important natural products, such… 
1995
1995
Farnesyl pyrophosphate synthase from white lupin: molecular cloning, expression, and purification of the expressed protein.
Plants produce a variety of sesquiterpenoid compounds with diverse biological functions, whose synthesis is initiated by farnesyl… 
Highly Cited
1990
Highly Cited
1990
Elucidation of the deficiency in two yeast coenzyme Q mutants. Characterization of the structural gene encoding hexaprenyl pyrophosphate synthetase.
Highly Cited
1989
Highly Cited
1989
Coordinate regulation of 3-hydroxy-3-methylglutaryl-coenzyme A synthase, 3-hydroxy-3-methylglutaryl-coenzyme A reductase, and prenyltransferase synthesis but not degradation in HepG2 cells.
Highly Cited
1989
Highly Cited
1989
Cloning, analysis, and bacterial expression of human farnesyl pyrophosphate synthetase and its regulation in Hep G2 cells.
A partial length cDNA encoding farnesyl pyrophosphate synthetase (hpt807) has been isolated from a human fetal liver cDNA library… 
1989
1989
Identification and regulation of a rat liver cDNA encoding farnesyl pyrophosphate synthetase.
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