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Factor Va

Known as: Activated Factor V, Blood Coagulation Factor V, Activated, Factor V, Activated 
Activated form of factor V. It is an essential cofactor for the activation of prothrombin catalyzed by factor Xa.
National Institutes of Health

Related topics

Related topics

8 relations
CoagulantsProcess of secretionagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2005
2005
Anti‐prothrombin IgG from patients with anti‐phospholipid antibodies inhibits the inactivation of factor Va by activated protein C
Interference of anti‐phospholipid antibodies with the protein C pathway has been suggested to play a role in the development of… 
2005
2005
Completed three-dimensional model of human coagulation factor va. Molecular dynamics simulations and structural analyses.
Factor Va is the critical cofactor for prothrombinase assembly required for timely and efficient prothrombin activation. In the… 
Highly Cited
2005
Highly Cited
2005
Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients.
To the Editor: The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, or statins, have been reported to exert… 
Highly Cited
2004
Highly Cited
2004
Unique in Vivo Modifications of Coagulation Factor V Produce a Physically and Functionally Distinct Platelet-derived Cofactor
Platelet- and plasma-derived factor Va (FVa) serve essential cofactor roles in prothrombinase-catalyzed thrombin generation… 
Highly Cited
2002
Highly Cited
2002
Molecular Characterization of an Extended Binding Site for Coagulation Factor Va in the Positive Exosite of Activated Protein C*
The anticoagulant human plasma serine protease, activated protein C (APC), inhibits blood coagulation by specific inactivation of… 
Highly Cited
2001
Highly Cited
2001
Simvastatin Depresses Blood Clotting by Inhibiting Activation of Prothrombin, Factor V, and Factor XIII and by Enhancing Factor Va Inactivation
BackgroundThe mechanism of the antithrombotic action of statins is unclear. The aim of this study was to evaluate the effects of… 
Highly Cited
1998
Highly Cited
1998
The SHBG‐like region of protein S is crucial for factor V‐dependent APC‐cofactor function
Highly Cited
1997
Highly Cited
1997
The effect of Arg306 → Ala and Arg506 → Gln substitutions in the inactivation of recombinant human factor Va by activated protein C and protein S
Factor Va (fVa) is inactivated by activated protein C (APC) by cleavage of the heavy chain at Arg306, Arg506, and Arg679. Site… 
Highly Cited
1996
Highly Cited
1996
Binding sites for blood coagulation factor Xa and protein S involving residues 493–506 in factor Va
Inactivation due to cleavage of Factor Va (FVa) at Arg 506 by activated protein C (APC) helps to downregulate blood coagulation… 
Highly Cited
1995
Highly Cited
1995
Use of a generally applicable tissue factor--dependent factor V assay to detect activated protein C-resistant factor Va in patients receiving warfarin and in patients with a lupus anticoagulant.
The original activated partial thromboplastin time-based assay for activated protein C (APC)-resistant factor Va (FVa) requires… 
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