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Factor Va

Known as: Activated Factor V, Blood Coagulation Factor V, Activated, Factor V, Activated 
Activated form of factor V. It is an essential cofactor for the activation of prothrombin catalyzed by factor Xa.
National Institutes of Health

Related topics

Related topics

8 relations
CoagulantsProcess of secretionagonistsantagonists & inhibitors

Papers overview

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2010
2010
Cellular regulation of blood coagulation: a model for venous stasis.
We have adapted the corn-trypsin inhibitor whole-blood model to include EA.hy926 as an endothelium surrogate to evaluate the… 
2008
2008
Effects of Prothrombin on the Individual Activated Protein C-mediated Cleavages of Coagulation Factor Va*
The factor Va (FVa) inactivation by activated protein C (APC), mediated by cleavages at Arg306 and Arg506 in FVa, is inhibited by… 
2008
2008
Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C
Summary The hypothesis that prothrombin (FII) protects coagulation factor Va (FVa) from proteolytic inactivation by activated… 
2004
2004
Enhanced Rate of Cleavage at Arg-306 and Arg-506 in Coagulation Factor Va by Gla Domain-mutated Human-activated Protein C*
A Gla domain-mutated protein C variant, QGNSEDY, modified at positions 10–12, 23, 32–33, and 44, having enhanced affinity for… 
2004
2004
Altered inactivation pathway of factor Va by activated protein C in the presence of heparin.
Inactivation of factor Va (FVa) by activated protein C (APC) is a predominant mechanism in the down-regulation of thrombin… 
1999
1999
Importance of individual activated protein C cleavage site regions in coagulation factor V for factor Va inactivation and for factor Xa activation.
Activated protein C (APC) cleavage of Factor Va (FVa) at residues R506 and R306 correlates with its inactivation. APC resistance… 
Highly Cited
1998
Highly Cited
1998
The SHBG‐like region of protein S is crucial for factor V‐dependent APC‐cofactor function
1998
1998
Flow cytometric analysis of agonist-induced annexin V, factor Va and factor Xa binding to human platelets.
Activated platelets provide a procoagulant surface for the assembly and expression of prothrombinase complex. Expression of… 
Highly Cited
1996
Highly Cited
1996
Binding sites for blood coagulation factor Xa and protein S involving residues 493–506 in factor Va
Inactivation due to cleavage of Factor Va (FVa) at Arg 506 by activated protein C (APC) helps to downregulate blood coagulation… 
1995
1995
Inhibitory activity of anti‐β2‐glycoprotein I antibody on factor va degradation by activated‐protein C and its cofactor protein S
We investigated the influence of anti‐β2‐glycoprotein I (aGPI), which recently has come to be regarded as anti‐cardiolipin… 
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