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FYX-051

 
National Institutes of Health

Papers overview

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2018
2018
Background and ObjectivesTopiroxostat—a novel selective xanthine oxidoreductase inhibitor—has been reported to reduce serum urate… Expand
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Highly Cited
2011
Highly Cited
2011
4-[5-(Pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile (FYX-051) is a potent inhibitor of bovine milk xanthine… Expand
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2010
2010
To clarify the toxicological aspects of FYX-051, a xanthine oxidoreductase inhibitor, which is currently being developed as a… Expand
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2009
2009
Our previous study identified 2-[2-(2-methoxyethoxy)ethoxy]-5-[5-(2-methyl-4-pyridyl)-1H-[1,2,4] triazol-3-yl]benzonitrile (2… Expand
2009
2009
The present studies were performed to investigate the possible mechanism of marked species differences on nephropathy found in… Expand
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2008
2008
Xanthine oxidoreductase (XOR) catalyzes the reaction of hypoxanthine to xanthine and of xanthine to uric acid. Inhibitors of XOR… Expand
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2007
2007
In humans, orally administered 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl) pyridine-2-carbonitrile (FYX-051) is excreted mainly as… Expand
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2006
2006
FYX-051, 4-(5-pyridin-4-yl-1H-[1,2,4]triazol-3-yl)pyridine-2-carbonitrile, is a novel xanthine oxidoreductase inhibitor that can… Expand
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2006
2006
To determine a rat strain appropriate for carcinogenicity testing of FYX-051, a xanthine oxidoreductase inhibitor, we performed a… Expand
2005
2005
The possible mechanism of the underlying nephropathy found in the rat toxicity study of FYX-051, a xanthine oxidoreductase… Expand