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topiroxostat

Known as: 4-(5-(Pyridin-4-yl)-1h-1,2,4-triazol-3-yl)pyridine-2-carbonitrile 
National Institutes of Health

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1 relation

Broader (1)

FYX-051

Papers overview

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2020
2020
Topiroxostat ameliorates oxidative stress and inflammation in sepsis-induced lung injury
Abstract Sepsis-induced lung injury was the most common cause of death in patients. Topiroxostat, a novel xanthine oxidoreductase… 
2019
2019
Changeover Trial of Febuxostat and Topiroxostat for Hyperuricemia with Cardiovascular Disease: Sub-Analysis for Chronic Kidney Disease (TROFEO CKD Trial)
Background: The TROFEO trial demonstrated that febuxostat causes greater and more rapid reduction of serum uric acid (s-UA) than… 
2019
2019
The effects of topiroxostat on vascular function in patients with hyperuricemia
Xanthine oxidoreductase (XOR) inhibitors, such as allopurinol and febuxostat, inhibit the catalysis of serum uric acid (SUA… 
2019
2019
RENAL PROTECTIVE EFFECTS OF TOPIROXOSTAT AND FEBUXISTAT, NEWLY AVAILABLE XANTHINE OXIDASE INHIBITORS
Objective:Control of uric acid level (UA) plays an important role in the protection of organs in hypertensive (HTN) patients… 
2018
2018
Evaluating Safety and efficacy in retrospective ANAlysis after switching Drug to topiroxostat Among patients with hyperuricemia study（SANADA study）
結 果 本研究の解析対象集団は対象基準を満たす 83名とした.なお,結果は average±SDもしく は,median[Q1, Q3]で表示する.Topの 24週間 投与で,本研究の主要評価項目であるL-FABP (μg /g・Cre)は7.6±8.0… 
2016
2016
Medicine composition with topiroxostat and application of medicine composition
The invention relates to a medicine composition with topiroxostat and application of the medicine composition, and belongs to the… 
2015
2015
Apoptosis induced by an uromodulin mutant C112Y and its suppression by topiroxostat
BackgroundFamilial juvenile hyperuricemic nephropathy (FJHN) is an autosomal dominant disorder caused by mutations in UMOD that… 
2014
2014
QT/QTc study conducted in Japanese adult healthy subjects: A novel xanthine oxidase inhibitor topiroxostat was not associated with QT prolongation
A QT/QTc study was conducted in compliance with ICH E14 guideline to evaluate the effects of a new xanthine oxidase inhibitor… 
2014
2014
A new xanthine oxidase inhibitor: the uric acid reduction and additional efficacy in CKD patients
2014
2014
Xanthine crystals induced by topiroxostat, a xanthine oxidoreductase inhibitor, in rats, cause transitional cell tumors
The present study was performed to elucidate the underlying mechanism of transitional cell tumors found in the carcinogenicity… 
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