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FR 900482

Known as: 3,9-Epoxy-3H-azirino(2,3-c)(1)benzazocine-5-carboxaldehyde, 8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,9,9a-hexahydro-7,9-dihydroxy-, FR-900482, FR900482 
National Institutes of Health

Related topics

Related topics

1 relation

Broader (1)

Oxazines

Papers overview

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2011
2011
Development of a flexible strategy towards FR900482 and the mitomycins.
FR900482 and the mitomycins are two intriguing classes of alkaloid natural products that have analogous biological mechanisms and… 
Highly Cited
2004
Highly Cited
2004
Three-component homo 3 + 2 dipolar cycloaddition. A diversity-oriented synthesis of tetrahydro-1,2-oxazines and FR900482 skeletal congeners.
[reaction: see text] The reaction of nitrones, formed in situ by reaction of hydroxylamines with aldehydes, with 1,1… 
2003
2003
Formal enantiospecific synthesis of (+)-FR900482.
The enantiospecific synthesis of FK973, and thus a formal enantiospecific synthesis of the antitumor antibiotic (+)-FR900482, is… 
2003
2003
Synthesis of the mitomycin and FR900482 ring systems via dimethyldioxirane oxidation.
[reaction: see text] Dimethyldioxirane oxidizes a 2,3-dihydo-1H-pyrrolo[1,2-a]indole unsubstituted at the C-9 position… 
2002
2002
Differential effects of FR900482 and FK317 on apoptosis, IL-2 gene expression, and induction of vascular leak syndrome.
2000
2000
FR900482 class of anti-tumor drugs cross-links oncoprotein HMG I/Y to DNA in vivo.
1988
1988
A new antitumor antibiotic, FR-900482: V. Interstrand DNA-DNA cross-links in L1210 cells.
FR-900482 (Fig. 1) is a new antitumor antibiotic isolated from the culture broth of Streptomyces sandaensis No. 68971~3). It has… 
Highly Cited
1987
Highly Cited
1987
A new antitumor antibiotic, FR-900482. III. Antitumor activity in transplantable experimental tumors.
FR-900482 (4-formyl-6,9-dihydroxy-14-oxa-1,11-diazatetracyclo[7.4.1.02,7, O10,12]tetradeca-2,4,6-triene-8-ylmethyl carbamate), a… 
1987
1987
A NEW ANTITUMOR ANTIBIOTIC, FR-900482
The new antibiotic FR-900482 (4-formyl-6, 9-dihydroxy-14-oxa-l, ll-diazatetracyclo[7.4.1.O2, 7.O10, 12]tetradeca-2, 4, 6-triene-8… 
1987
1987
A new antitumor antibiotic, FR-900482. I. Taxonomic studies on the producing strain: a new species of the genus Streptomyces.
A new species in the genus Streptomyces, for which the name Streptomyces sandaensis sp. nov. is proposed, is described. Soil… 
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