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FK-506, a novel immunosuppressant isolated from a Streptomyces. I. Fermentation, isolation, and physico-chemical and biological characteristics.
FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as colorless prism and the molecular formula was determined as C44H69NO12.H2O.…
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FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.
TLDR
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 and gamma-interferon and the expression of the IL-2 receptor were suppressed by this agent.
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Discovery of FK-506, a novel immunosuppressant isolated from Streptomyces tsukubaensis.
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Immunosuppressive effect of FK506 on collagen-induced arthritis in rats.
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Studies on new phosphonic acid antibiotics. I. FR-900098, isolation and characterization.
TLDR
A strain of Streptomyces, isolated from a soil sample, has been found to produce FR-900098, an interesting new antibiotic containing phosphorus in its molecule, which was shown to inhibit a wide variety of Gram-negative bacteria including Pseudomonas, Proteus, and Escherichia coli.
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Studies on a new immunoactive peptide, FK-156. II. Fermentation, extraction and chemical and biological characterization.
TLDR
Pretreatment of mice or rats with this peptide protected the animals against lethal infection with Escherichia coli and resulted in prolongation of life span of tumor bearing animals.
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STUDIES ON NEW PHOSPHONIC ACID ANTIBIOTICS
TLDR
A strain of Streptomyces, isolated from a soil sample, has been found to produce FR-900098, an interesting new antibiotic containing phosphorus in its molecule, which was shown to inhibit a wide variety of Gram-negative bacteria including Pseudomonas, Proteus, and Escherichia coli.
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Effect of FK-506 on human mixed lymphocyte reaction in vitro.
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FK 506: historical perspectives.
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NOCARDICIN A, A NEW MONOCYCLIC β-LACTAM ANTIBIOTIC
TLDR
Nocardicin A is a new monocyclic β-lactam antibiotic obtained from the fermentation broth of a strain of actinomycetes that exhibits moderate in vitro antibacterial activity against a broad-spectrum of Gram-negative bacteria including Proteus and Pseudomonas.
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