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FOXL2 gene

Known as: PITUITARY FORKHEAD FACTOR, MOUSE, HOMOLOG OF, BPES1, FOXL2 
This gene plays a role in ovarian function.
National Institutes of Health

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Related topics

9 relations
ApoptosisCell Differentiation processForkhead Box Protein L2Homo sapiens

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FOXL2 wt Allele

Papers overview

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Highly Cited
2013
Highly Cited
2013
Antagonistic roles of Dmrt1 and Foxl2 in sex differentiation via estrogen production in tilapia as demonstrated by TALENs.
Transcription activator-like effector nucleases (TALENs) are a powerful approach for targeted genome editing and have been proved… 
Highly Cited
2011
Highly Cited
2011
FOXL2 Is a Sensitive and Specific Marker for Sex Cord-Stromal Tumors of the Ovary
Sex cord-stromal tumors (SCSTs) of the ovary are relatively uncommon tumors. Diagnosis of SCST rests primarily on the… 
Highly Cited
2009
Highly Cited
2009
Foxl2 functions in sex determination and histogenesis throughout mouse ovary development
BackgroundPartial loss of function of the transcription factor FOXL2 leads to premature ovarian failure in women. In animal… 
Review
2006
Review
2006
Ovarian follicle development and transgenic mouse models.
Ovarian follicle development is a complex process that begins with the establishment of what is thought to be a finite pool of… 
Highly Cited
2005
Highly Cited
2005
Aromatase inhibition reduces expression of FOXL2 in the embryonic chicken ovary
P450‐aromatase is the terminal estrogen‐synthesizing enzyme and a key gene in avian sex determination. Aromatase is expressed… 
Review
2004
Review
2004
Human FOX gene family (Review).
Human Forkhead-box (FOX) gene family consists of at least 43 members, including FOXA1, FOXA2, FOXA3, FOXB1, FOXC1, FOXC2, FOXD1… 
Highly Cited
2004
Highly Cited
2004
Forkhead l2 is expressed in the ovary and represses the promoter activity of the steroidogenic acute regulatory gene.
Premature ovarian failure in a subgroup of women with blepharophimosis-ptosis-epicanthus inversus type 1 syndrome has been… 
Highly Cited
2003
Highly Cited
2003
Etiology of ovarian failure in blepharophimosis ptosis epicanthus inversus syndrome: FOXL2 is a conserved, early-acting gene in vertebrate ovarian development.
Blepharophimosis ptosis epicanthus inversus syndrome (BPES) is a human disorder caused by mutations in the forkhead transcription… 
Highly Cited
2002
Highly Cited
2002
Identification of novel mutations in FOXL2 associated with premature ovarian failure.
Premature ovarian failure (POF) affects approximately 1% of women and is known to be caused by sex chromosome abnormalities… 
Highly Cited
2001
Highly Cited
2001
Spectrum of FOXL2 gene mutations in blepharophimosis-ptosis-epicanthus inversus (BPES) families demonstrates a genotype--phenotype correlation.
Mutations in FOXL2, a forkhead transcription factor gene, have recently been shown to cause blepharophimosis-ptosis-epicanthus… 
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