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High resolution of human evolutionary trees with polymorphic microsatellites
TLDR
It is shown that polymorphic microsatellites (primarily CA repeats) allow trees of human individuals to be constructed that reflect their geographic origin with remarkable accuracy by the analysis of a large number of loci for each individual, in spite of the small variations in allele frequencies existing between populations. Expand
The Simons Genome Diversity Project: 300 genomes from 142 diverse populations
TLDR
It is demonstrated that indigenous Australians, New Guineans and Andamanese do not derive substantial ancestry from an early dispersal of modern humans; instead, their modern human ancestry is consistent with coming from the same source as that of other non-Africans. Expand
Ancient human genomes suggest three ancestral populations for present-day Europeans
TLDR
It is shown that the great majority of present-day Europeans derive from at least three highly differentiated populations: West European Hunter-Gatherers (WHG), who contributed ancestry to all Europeans but not to Near Easterners; Ancient North Eurasians (ANE); and Early European Farmers (EEF), who were mainly of Near Eastern origin but also harbored WHG-related ancestry. Expand
Reconstructing Native American Population History
TLDR
It is shown that the initial peopling followed a southward expansion facilitated by the coast, with sequential population splits and little gene flow after divergence, especially in South America. Expand
Genetic Variation and Population Structure in Native Americans
TLDR
Evidence is observed of a higher level of diversity and lower level of population structure in western South America compared to eastern South America, a relative lack of differentiation between Mesoamerican and Andean populations, and a partial agreement on a local scale between genetic similarity and the linguistic classification of populations. Expand
Geographic Patterns of Genome Admixture in Latin American Mestizos
TLDR
An analysis of admixture in thirteen Mestizo populations from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites found extensive variation in Native American and European ancestry among populations and individuals and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. Expand
Discerning the Ancestry of European Americans in Genetic Association Studies
TLDR
Empirical patterns of population structure in European Americans are investigated, analyzing 4,198 samples from four genome-wide association studies to show that components roughly corresponding to northwest European, southeast European, and Ashkenazi Jewish ancestry are the main sources of European American population structure. Expand
A Gain-of-Function Mutation in TRPA1 Causes Familial Episodic Pain Syndrome
TLDR
An autosomal-dominant familial episodic pain syndrome characterized by episodes of debilitating upper body pain, triggered by fasting and physical stress is described, providing evidence that variation in the TRPA1 gene can alter pain perception in humans. Expand
Admixture dynamics in Hispanics: a shift in the nuclear genetic ancestry of a South American population isolate.
TLDR
Interestingly, despite a nearly complete Native American mtDNA background, Antioquia has a markedly predominant European ancestry at the autosomal and X chromosome level, which suggests that, after foundation, continuing admixture with Spanish men (but not with native women) increased the European nuclear ancestry of Antioqia. Expand
The genetics of Mexico recapitulates Native American substructure and affects biomedical traits
TLDR
Pre-Columbian genetic substructure is recapitulated in the indigenous ancestry of admixed mestizo individuals across the country, and two independently phenotyped cohorts of Mexicans and Mexican Americans showed a significant association between subcontinental ancestry and lung function. Expand
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