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FOLFOX Regimen

Known as: CF/5-FU/L-OHP, FOLFOX, Fluorouracil/Leucovorin Calcium/Oxaliplatin 
An abbreviation for a chemotherapy combination used to treat colorectal cancer that is advanced or has come back. It is also being studied in the… 
National Institutes of Health

Related topics

Related topics

4 relations
FluorouracilFolfox protocolLeucovorin Calciumoxaliplatin

Papers overview

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Review
2013
Review
2013
Localized colon cancer, version 3.2013: featured updates to the NCCN Guidelines.
The NCCN Clinical Practice Guidelines in Oncology for Colon Cancer begin with the clinical presentation of the patient to the… 
Review
2013
Review
2013
Molecularly targeted drugs for metastatic colorectal cancer
The survival rate of patients with metastatic colorectal cancer (mCRC) has significantly improved with applications of… 
Highly Cited
2012
Highly Cited
2012
Irinotecan Drug-Eluting Beads in the Treatment of Chemo-Naive Unresectable Colorectal Liver Metastasis with Concomitant Systemic Fluorouracil and Oxaliplatin: Results of Pharmacokinetics and Phase I…
PurposeThe primary objective of this study is to evaluate the safety, tolerance, and pharmacokinetic profile of liver-directed… 
Highly Cited
2012
Highly Cited
2012
Association between VEGF Splice Isoforms and Progression-Free Survival in Metastatic Colorectal Cancer Patients Treated with Bevacizumab
Purpose: Bevacizumab improves survival for patients with metastatic colorectal cancer with chemotherapy, but no proven predictive… 
Highly Cited
2010
Highly Cited
2010
A phase I study of axitinib (AG-013736) in combination with bevacizumab plus chemotherapy or chemotherapy alone in patients with metastatic colorectal cancer and other solid tumors.
BACKGROUND Axitinib and bevacizumab are targeted therapies against the vascular endothelial growth factor pathway. METHODS… 
Highly Cited
2009
Highly Cited
2009
Outcome of primary tumor in patients with synchronous stage IV colorectal cancer receiving combination chemotherapy without surgery as initial treatment.
CRA4030 Background: In the absence of symptoms (bleeding, perforation, obstruction) or resectable metastatic disease, primary… 
Highly Cited
2008
Highly Cited
2008
Phase II trial of FOLFOX plus bevacizumab in advanced, progressive neuroendocrine tumors
15545 Background: Inhibitors of the VEGF pathway have been shown to have activity in neuroendocrine tumors (NET). Oxaliplatin… 
Highly Cited
2006
Highly Cited
2006
Which Gene is a Dominant Predictor of Response During FOLFOX Chemotherapy for the Treatment of Metastatic Colorectal Cancer, the MTHFR or XRCC1 Gene?
BackgroundCombination chemotherapy using oxaliplatin, 5-fluorouracil and folinic acid (FOLFOX) is known to be effective in the… 
Highly Cited
2004
Highly Cited
2004
Oxaliplatin plus high-dose leucovorin and 5-fluorouracil (FOLFOX 4) in platinum-resistant and taxane-pretreated ovarian cancer: a phase II study.
Highly Cited
2004
Highly Cited
2004
OPTIMOX study: FOLFOX 7/LV5FU2 compared to FOLFOX 4 in patients with advanced colorectal cancer.
3525 Background: FOLFOX4 has shown superiority over LV5FU2 and IFL in first line therapy. Limiting toxicities are neutropenia… 
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