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Fluorouracil

Known as: 5-Fluracil, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, Fluouracil 
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a… 
National Institutes of Health

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Related topics

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10 ML Fluorouracil 50 MG/ML InjectionCAFVP protocolCFP protocolCMF-B protocol

Narrower (19)

COFP protocol 1CytosafeFCC protocolFDV protocol

Papers overview

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2008
2008
Surgery with curative intent in patients (pts) treated with first-line chemotherapy (CT) + bevacizumab (BEV) for metastatic colorectal cancer (mCRC): First BEAT and NO16966
4022 Background: Resection of initially unresectable metastatic lesions in pts with mCRC who have responded to systemic therapy… 
2004
2004
Bevacizumab (BV) plus 5-FU/leucovorin (FU/LV) for advanced colorectal cancer (CRC) that progressed after standard chemotherapies: An NCI Treatment Referral Center trial (TRC-0301).
3515 Background: The addition of bevacizumab (BV, Avastin) to IFL for untreated metastatic CRC produces survival benefit (Hurwitz… 
Highly Cited
1993
Highly Cited
1993
Phase II study of cisplatin and 120-hour continuous infusion of 5-fluorouracil in patients with advanced pancreatic adenocarcinoma.
BACKGROUND Advanced pancreatic carcinoma (APC) is a rapidly fatal disease and an active chemotherapy with palliative effects and… 
1992
1992
[Randomized study of preoperative chemotherapy in squamous cell cancer of the esophagus. CAO Esophageal Cancer Study Group].
  • P. Schlag
  • Der Chirurg; Zeitschrift fur alle Gebiete der…
  • 1992
  • Corpus ID: 43471225
Only 46 of 77 patients with potentially resectable squamous cell carcinoma of the esophagus who were asked to participate in a… 
Highly Cited
1985
Highly Cited
1985
Tissue-specific Enhancement of Uridine Utilization and 5-Fluorouracil Therapy in Mice by Benzylacyclouridine
Abstract Benzylacyclouridine (BAU), a potent inhibitor of uridine phosphorylase, delays the disappearance of uridine from plasma… 
1985
1985
Allopurinol mouthwashes and 5-fluorouracil induced oral toxicity.
: Allopurinol has been shown to decrease the gastro-intestinal and bone marrow toxicity of 5-fluorouracil. In an attempt to… 
Highly Cited
1984
Highly Cited
1984
Effect of biological time on the determination of the LD50 of 5-fluorouracil in mice.
The LD50 was determined for 5-fluorouracil (FU) in mice at 11.00 and 23.00 h during one 24-hour period. These times were chosen… 
1983
1983
Conservative management without alkylating agents of squamous cell anal cancer using cyclical 5-FU alone and x-ray therapy.
We have treated 11 patients with squamous cell anal carcinoma using a regimen of repeated cycles of 120-hour infused 5-FU (25 mg… 
Highly Cited
1977
Highly Cited
1977
A model for prediction of chemotherapy response to 5-fluorouracil based on the differential distribution of 5-[18F]fluorouracil in sensitive versus resistant lymphocytic leukemia in mice.
The distribution of 5-[18F]fluorouracil has been compared in two variants of the same tumor in c57bL X DBA/2 F1 mice: solid L1210… 
1969
1969
Influence of ribose donors on the action of 5-fluorouracil.
Although the most potent antimetabolite formed from 5-fluorouracil in vivo is a deoxyribonucleotide, evidence has accumulated…