Fluorouracil

Known as: 5-Fluracil, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, Fluouracil 
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
05001000150019462016

Related topics

Related topics

48 relations
10 ML Fluorouracil 50 MG/ML InjectionCAFVP protocolCFP protocolCMFVP protocol
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Narrower (18)

CytosafeFCC protocolFDV protocolFMP protocol
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Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Fluorouracil
Communicable Diseases
Colonic Neoplasms
FOLFOX Regimen
doxorubicin/fluorouracil/semustine protocol
CFP protocol

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Autophagy in 5-Fluorouracil Therapy in Gastrointestinal Cancer: Trends and Challenges
OBJECTIVE 5-Fluorouracil (5-FU)-based combination therapies are standard treatments for gastrointestinal cancer, where the… (More)
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Review
2016
Review
2016
The evolving role of microsatellite instability in colorectal cancer: A review.
Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR) system and occurs in approximately 15… (More)
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Highly Cited
2009
Highly Cited
2009
Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer.
PURPOSE This randomized study assessed whether the best overall response rate (ORR) of cetuximab combined with oxaliplatin… (More)
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Highly Cited
2007
Highly Cited
2007
Cisplatin and fluorouracil alone or with docetaxel in head and neck cancer.
BACKGROUND A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction… (More)
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Highly Cited
2004
Highly Cited
2004
Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer.
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… (More)
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Highly Cited
2004
Highly Cited
2004
Oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment for colon cancer.
BACKGROUND The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the… (More)
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Highly Cited
2003
Highly Cited
2003
Tumor microsatellite-instability status as a predictor of benefit from fluorouracil-based adjuvant chemotherapy for colon cancer.
BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish… (More)
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Highly Cited
2000
Highly Cited
2000
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial.
BACKGROUND Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.
PURPOSE In a previous study of treatment for advanced colorectal cancer, the LV5FU2 regimen, comprising leucovorin (LV) plus… (More)
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Irinotecan plus fluorouracil and leucovorin for metastatic colorectal cancer. Irinotecan Study Group.
BACKGROUND The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal… (More)
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