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Fluorouracil

Known as: 5-Fluracil, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, Fluouracil 
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a… 
National Institutes of Health

Related topics

Related topics

49 relations
10 ML Fluorouracil 50 MG/ML InjectionCAFVP protocolCFP protocolCMF-B protocol

Narrower (19)

COFP protocol 1CytosafeFCC protocolFDV protocol

Papers overview

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Highly Cited
2011
Highly Cited
2011
Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer.
PURPOSE This multicenter, randomized trial compared capecitabine plus oxaliplatin (XELOX) with bolus fluorouracil (FU) and… 
Highly Cited
2010
Highly Cited
2010
Prognostic and predictive value of the 21-gene recurrence score assay in postmenopausal women with node-positive, oestrogen-receptor-positive breast cancer on chemotherapy: a retrospective analysis…
Highly Cited
2007
Highly Cited
2007
Body Composition as an Independent Determinant of 5-Fluorouracil–Based Chemotherapy Toxicity
Purpose: Evidence suggests that lean body mass (LBM) may be useful to normalize doses of chemotherapy. Data from a prospective… 
Highly Cited
2007
Highly Cited
2007
Oxaliplatin combined with weekly bolus fluorouracil and leucovorin as surgical adjuvant chemotherapy for stage II and III colon cancer: results from NSABP C-07.
PURPOSE This phase III clinical trial evaluated the impact on disease-free survival (DFS) of adding oxaliplatin to bolus weekly… 
Highly Cited
2006
Highly Cited
2006
Liver histology and surgical outcomes after preoperative chemotherapy with fluorouracil plus oxaliplatin in colorectal cancer liver metastases.
PURPOSE Preoperative chemotherapy for colorectal liver metastases (CLM) can produce histologic changes in the nontumor-bearing… 
Highly Cited
2002
Highly Cited
2002
First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin.
PURPOSE To evaluate the safety profile of capecitabine using data from a large, well-characterized population of patients with… 
Highly Cited
1994
Highly Cited
1994
Improving adjuvant therapy for rectal cancer by combining protracted-infusion fluorouracil with radiation therapy after curative surgery.
BACKGROUND The combination of radiation therapy and chemotherapy with fluorouracil plus semustine after surgery has been… 
Highly Cited
1992
Highly Cited
1992
Randomized comparison of cisplatin plus fluorouracil and carboplatin plus fluorouracil versus methotrexate in advanced squamous-cell carcinoma of the head and neck: a Southwest Oncology Group study.
PURPOSE The Southwest Oncology Group (SWOG) conducted a randomized comparison of cisplatin plus fluorouracil (5-FU) and… 
Highly Cited
1990
Highly Cited
1990
Identification, purification, and biological characterization of hematopoietic stem cell factor from buffalo rat liver-conditioned medium
Review
1989
Review
1989
Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma.
The purpose of this study was to evaluate the effectiveness of several new approaches designed to enhance the activity of… 
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