Fluorouracil

Known as: 5-Fluracil, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, Fluouracil 
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1946-2017
05001000150019462016

Papers overview

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Review
2016
Review
2016
OBJECTIVE 5-Fluorouracil (5-FU)-based combination therapies are standard treatments for gastrointestinal cancer, where the… (More)
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Review
2016
Review
2016
Microsatellite instability (MSI) is a molecular marker of a deficient mismatch repair (MMR) system and occurs in approximately 15… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE This randomized study assessed whether the best overall response rate (ORR) of cetuximab combined with oxaliplatin… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the… (More)
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Highly Cited
2003
Highly Cited
2003
BACKGROUND Colon cancers with high-frequency microsatellite instability have clinical and pathological features that distinguish… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We… (More)
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Highly Cited
2000
Highly Cited
2000
PURPOSE In a previous study of treatment for advanced colorectal cancer, the LV5FU2 regimen, comprising leucovorin (LV) plus… (More)
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal… (More)
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