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Fluorouracil

Known as: 5-Fluracil, 5-Fluoro-2,4(1H,3H)-pyrimidinedione, Fluouracil 
An antimetabolite fluoropyrimidine analog of the nucleoside pyrimidine with antineoplastic activity. Fluorouracil and its metabolites possess a… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Importance Patients with locally advanced pancreatic cancer have historically poor outcomes. Evaluation of a total neoadjuvant… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND Phase 2 studies suggest that the standard regimen of cisplatin and fluorouracil (PF) plus docetaxel (TPF) improves… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND A randomized phase 3 trial of the treatment of squamous-cell carcinoma of the head and neck compared induction… Expand
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Highly Cited
2006
Highly Cited
2004
Highly Cited
2004
BACKGROUND Bevacizumab, a monoclonal antibody against vascular endothelial growth factor, has shown promising preclinical and… Expand
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Highly Cited
2004
Highly Cited
2004
BACKGROUND The standard adjuvant treatment of colon cancer is fluorouracil plus leucovorin (FL). Oxaliplatin improves the… Expand
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Review
2003
Review
2003
5-Fluorouracil (5-FU) is widely used in the treatment of cancer. Over the past 20 years, increased understanding of the mechanism… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND Irinotecan is active against colorectal cancer in patients whose disease is refractory to fluorouracil. We… Expand
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Highly Cited
2000
Highly Cited
2000
PURPOSE In a previous study of treatment for advanced colorectal cancer, the LV5FU2 regimen, comprising leucovorin (LV) plus… Expand
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Highly Cited
2000
Highly Cited
2000
BACKGROUND The combination of fluorouracil and leucovorin has until recently been standard therapy for metastatic colorectal… Expand
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