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FLJ10858 protein, human

Known as: DNA Glycosylase hFPG2, FPG2 protein, human, Nei-Like Protein 3 
Endonuclease 8-like 3 (605 aa, ~68 kDa) is encoded by the human NEIL3 gene. This protein plays a role in binding and repair of single-stranded DNA.
National Institutes of Health

Related topics

Related topics

10 relations
Base Excision RepairCell NucleusDNA RepairDNA Repair Endonuclease

Broader (1)

N-Glycosyl Hydrolases

Papers overview

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Review
2020
Review
2020
Oxidative DNA-protein crosslinks formed in mammalian cells by abasic site lyases involved in DNA repair.
2019
2019
A Novel ALDH1A1 Inhibitor Targets Cells with Stem Cell Characteristics in Ovarian Cancer
A small of population of slow cycling and chemo-resistant cells referred to as cancer stem cells (CSC) have been implicated in… 
2019
2019
Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
2017
2017
Loss of NEIL3 DNA glycosylase markedly increases replication associated double strand breaks and enhances sensitivity to ATR inhibitor in glioblastoma cells
DNA endonuclease eight-like glycosylase 3 (NEIL3) is one of the DNA glycosylases that removes oxidized DNA base lesions from… 
2016
2016
Ginsenoside Rd Attenuates DNA Damage by Increasing Expression of DNA Glycosylase Endonuclease VIII-like Proteins after Focal Cerebral Ischemia
Background:Ginsenoside Rd (GSRd), one of the main active ingredients in traditional Chinese herbal Panax ginseng, has been found… 
2016
2016
Neil3 induced neurogenesis protects against prion disease during the clinical phase
Base excision repair (BER) is the major pathway for repair of oxidative DNA damage. Mice with genetic knockout of the BER enzyme… 
Highly Cited
2015
Highly Cited
2015
The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
G-quadruplex is a four-stranded G-rich DNA structure that is highly susceptible to oxidation. Despite the important roles that G… 
Review
2015
Review
2015
Genetic variants in the DNA repair gene NEIL3 and the risk of myocardial infarction in a nested case-control study. The HUNT Study.
2013
2013
Association of polymorphisms in FLT3, EGFR, ALOX5, and NEIL3 with glioblastoma in the Han Chinese population
Glioblastoma (GBM) is the highest-grade glioma in astrocytoma. Patients often have poor prognosis due to therapeutic resistance… 
2013
2013
Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight
The incidence of type 2 diabetes is rising rapidly because of an increase in the incidence of being overweight and obesity… 
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