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Oxidative DNA damage is epigenetic by regulating gene transcription via base excision repair
It is demonstrated that ROS-mediated oxidation of DNA to yield 8-oxo-7,8-dihydroguanine in gene promoters is a signaling agent for gene activation and an epigenetic modification and G-quadruplex–forming sequences can serve as sensors of oxidative stress.
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo
The characterization of Mus musculus (house mouse) Neil3 (MmuNeil3) as an active DNA glycosylase both in vitro and in vivo is reported, suggesting that Neil3 plays a role in repairing FapyG in vivo.
Sequencing the Mouse Genome for the Oxidatively Modified Base 8-Oxo-7,8-dihydroguanine by OG-Seq.
Genetic promoters and UTRs harbor more OG-enriched sites than expected if the sites were randomly distributed throughout the genome and correlate with reactive 5'-GG-3' sequences, a result supporting decades of in vitro studies.
Characterization of hydantoin products from one-electron oxidation of 8-oxo-7,8-dihydroguanosine in a nucleoside model.
To thoroughly characterize the structure of this lesion, the oxidation of the nucleoside 9-N-(2',3',5'-tri-O-acetyl-beta-D-erythro-pentanosyl)-8-oxo-7,8-dihydroguanine with one-electron oxidants at pH 2-4 was used as a model for duplex DNA oxidation of OG residues.
Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.
The DNA glycosylase hNEIL1 initiates the base excision repair (BER) of a diverse array of lesions, including ring-opened purines and saturated pyrimidines. Of these, the hydantoin lesions,
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coli.
Results suggest a protective function for MutY in preventing mutation as a result of A (G) incorporation opposite Gh(Sp) during DNA replication, as well as three oxidized base-specific DNA glycosylases of Escherichia coli.
Zika Virus Genomic RNA Possesses Conserved G-Quadruplexes Characteristic of the Flaviviridae Family
Zika virus has emerged as a global concern because neither a vaccine nor antiviral compounds targeting it exist. A structure for the positive-sense RNA genome has not been established, leading us to