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Repair of oxidative damage to DNA: enzymology and biology.
Using AP Endonucleases as Metalloproteins as TrimMing for Reduction of DEOXYRIBOSE DAMages is suggested. Expand
Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6
It is demonstrated that SIRT6 is a nuclear, chromatin-associated protein that promotes resistance to DNA damage and suppresses genomic instability in mouse cells, in association with a role in base excision repair (BER). Expand
Genome-Wide Transcriptional Profiling of theEscherichia coli Responses to Superoxide Stress and Sodium Salicylate
The genetic responses to both environmental insults revealed several common themes, including the activation of genes coding for functions that replenish reducing potential; regulate iron transport and storage; and participate in sugar and amino acid transport, detoxification, protein modification, osmotic protection, and peptidoglycan synthesis. Expand
Redox-operated genetic switches: the SoxR and OxyR transcription factors.
Two redox-responsive transcription regulators have been well defined in Escherichia coli and serve as paradigms of redox-operated genetic switches. SoxR contains iron-sulfur centers that activate theExpand
Positive control of a global antioxidant defense regulon activated by superoxide-generating agents in Escherichia coli.
The identified genetic locus, soxR (superoxide response), that positively regulates 9 of these proteins during superoxide stress may operate as an inducible defense against xenobiotics in general. Expand
Crystal structure of the Escherichia coli Rob transcription factor in complex with DNA
A 2.7 Å crystal structure of Rob in complex with the micF promoter that reveals an unusual mode of binding to DNA and suggests that gene activation by AraC/XylS transcription factors might involve two alternative modes ofbinding to DNA in different promoter contexts. Expand
The exonuclease TREX1 is in the SET complex and acts in concert with NM23-H1 to degrade DNA during granzyme A-mediated cell death.
This work has found the 3'-to-5' exonuclease TREX1, but not its close homolog TREX2, in the SET complex, which resides in an endoplasmic reticulum-associated complex that translocates to the nucleus in response to superoxide generation by granzyme A. Expand
Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob protein
Overexpression of Rob conferred multiple antibiotic resistance similar to that known for SoxS and MarA (against chloramphenicol, tetracycline, nalidixic acid, and puromycin), as well as resistance to the superoxide-generating compound phenazine methosulfate. Expand
Interaction of human apurinic endonuclease and DNA polymerase beta in the base excision repair pathway.
Kinetic experiments indicated that Ape accelerates the excision of 5'-terminal deoxyribose 5-phosphate by Polbeta, indicating that the two central players of the base excision repair pathway are coordinated in sequential reactions. Expand
Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulon.
DNA sequence analysis revealed the presence of two genes involved in activating the soxR regulon, and indicates that SoxR and SoxS may constitute a novel type of two-component regulatory system in which the two proteins act sequentially to activate transcription of the various regulon genes in response to superoxide stress. Expand