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FK-506

Known as: FK 506, FK506 
 
National Institutes of Health

Papers overview

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Review
1993
Review
1993
FK-506 and cyclosporin A (CsA) are potent immunosuppressive agents used clinically to prevent tissue rejection. Interest in the… Expand
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Highly Cited
1993
Highly Cited
1993
The ryanodine receptor/calcium release channel (CRC) of rabbit skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum… Expand
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Highly Cited
1992
Highly Cited
1992
ANTIGEN recognition by the T-cell receptor (TCR) initiates events including lymphokine gene transcription1, particularly… Expand
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Highly Cited
1992
Highly Cited
1992
FK-506 inhibits Ca(2+)-dependent transcription of lymphokine genes in T cells, and thereby acts as a powerful immunosuppressant… Expand
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Highly Cited
1991
Highly Cited
1991
CYCLOSPORINA and FK506 inhibit T- and B-cell activation and other processes essential to an effective immune response1–3. In T… Expand
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Highly Cited
1990
Highly Cited
1990
FK-506 and the structurally related macrolide rapamycin (RAP) were investigated in comparison with cyclosporin A (CsA) for their… Expand
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Highly Cited
1990
Highly Cited
1990
The structurally related immunosuppressive macrolides FK-506 and rapamycin (RAP) were previously shown to inhibit T cell… Expand
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Highly Cited
1989
Highly Cited
1989
CYCLOSPORIN A and the newly discovered immunosuppressant, FK-506, are potent inhibitors of T cell activation1. In addition to… Expand
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Highly Cited
1987
Highly Cited
1987
FK-506, a novel immunosuppressant, has been isolated from the fermentation broth of Streptomyces tsukubaenis No. 9993 as… Expand
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Highly Cited
1987
Highly Cited
1987
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We… Expand
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