FK-506

Known as: FK 506, FK506 
 
National Institutes of Health

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Highly Cited
2005
Highly Cited
2005
BACKGROUND Drugs released from stents affect the biology of vascular cells. We examined the effect of rapamycin and FK-506 on… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND AND PURPOSE The etiology of the neurotoxicity associated with cyclosporin-A (CsA) and FK-506 treatment is not fully… (More)
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Review
1993
Review
1993
FK-506 and cyclosporin A (CsA) are potent immunosuppressive agents used clinically to prevent tissue rejection. Interest in the… (More)
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Highly Cited
1993
Highly Cited
1993
The ryanodine receptor/calcium release channel (CRC) of rabbit skeletal muscle terminal cisternae (TC) of sarcoplasmic reticulum… (More)
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Highly Cited
1992
Highly Cited
1992
ANTIGEN recognition by the T-cell receptor (TCR) initiates events including lymphokine gene transcription1, particularly… (More)
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Highly Cited
1992
Highly Cited
1992
FK-506 inhibits Ca(2+)-dependent transcription of lymphokine genes in T cells, and thereby acts as a powerful immunosuppressant… (More)
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Highly Cited
1991
Highly Cited
1991
CYCLOSPORINA and FK506 inhibit T- and B-cell activation and other processes essential to an effective immune response1–3. In T… (More)
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Highly Cited
1990
Highly Cited
1990
FK-506 and the structurally related macrolide rapamycin (RAP) were investigated in comparison with cyclosporin A (CsA) for their… (More)
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Highly Cited
1990
Highly Cited
1990
The structurally related immunosuppressive macrolides FK-506 and rapamycin (RAP) were previously shown to inhibit T cell… (More)
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Highly Cited
1987
Highly Cited
1987
The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We… (More)
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