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FGFR4 wt Allele

Known as: JTK2, Fibroblast Growth Factor Receptor 4 wt Allele, CD334 
Human FGFR4 wild-type allele is located within 5q35.1-qter and is approximately 11 kb in length. This allele, which encodes fibroblast growth factor… 
National Institutes of Health

Related topics

Related topics

16 relations
5q35.1-qterBreast CarcinomaCarcinoma of lungCell Differentiation process

Broader (1)

FGFR4 gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2018
Highly Cited
2018
Downregulation of miR‐491‐5p promotes gastric cancer metastasis by regulating SNAIL and FGFR4
Gastric cancer (GC) is among the most fatal cancers in China. MicroRNAs (miRNAs) are versatile regulators during GC development… 
2016
2016
Molecular subclasses of hepatocellular carcinoma predict sensitivity to fibroblast growth factor receptor inhibition
A recent gene expression classification of hepatocellular carcinoma (HCC) includes a poor survival subclass termed S2… 
Review
2015
Review
2015
Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a lethal cancer with limited systemic therapeutic options. Liver carcinogenesis is a complex… 
Highly Cited
2012
Highly Cited
2012
Targeting FGFR4 Inhibits Hepatocellular Carcinoma in Preclinical Mouse Models
The fibroblast growth factor (FGF)-FGF receptor (FGFR) signaling system plays critical roles in a variety of normal developmental… 
2012
2012
Differential effects of polymorphic alleles of FGF receptor 4 on colon cancer growth and metastasis.
A gly(388)arg polymorphism (rs351855) in the transmembrane domain of the fibroblast growth factor receptor (FGFR4) is associated… 
Highly Cited
2010
Highly Cited
2010
The Receptor Tyrosine Kinase FGFR4 Negatively Regulates NF-kappaB Signaling
Background NFκB signaling is of paramount importance in the regulation of apoptosis, proliferation, and inflammatory responses… 
2009
2009
Resident hepatocyte fibroblast growth factor receptor 4 limits hepatocarcinogenesis
Fibroblast growth factor (FGF) family signaling mediates cell‐to‐cell communication in development and organ homeostasis in… 
2007
2007
Analysis of Mammalian Carboxylesterase Inhibition by Trifluoromethylketone-Containing Compounds
Carboxylesterases (CE) are ubiquitous enzymes that hydrolyze numerous ester-containing xenobiotics, including complex molecules… 
2005
2005
FGF19‐FGFR4 signaling elaborates lens induction with the FGF8‐L‐Maf cascade in the chick embryo
The fibroblast growth factor (FGF) family is known to be involved in vertebrate eye development. However, distinct roles of… 
Highly Cited
2004
Highly Cited
2004
Involvement of the FGFR4 Arg388 allele in head and neck squamous cell carcinoma
Fibroblast growth factor receptors (FGFRs) have been implicated in various forms of human hyperproliferative disorders such as… 
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