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FECH gene

Known as: IRON CHELATASE, FECH, HEME SYNTHASE 
National Institutes of Health

Related topics

Related topics

3 relations
Erythropoietic ProtoporphyriaFERROCHELATASEferrochelatase activity

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2006
2006
A new class of [2Fe-2S]-cluster-containing protoporphyrin (IX) ferrochelatases.
Protoporphyrin (IX) ferrochelatase catalyses the insertion of ferrous iron into protoporphyrin IX to form haem. These… 
Highly Cited
2002
Highly Cited
2002
An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria.
Protoporphyria is generally inherited as an autosomal dominant disorder. The enzymatic defect of protoporphyria is a deficiency… 
Highly Cited
2002
Highly Cited
2002
Expression analysis of the two ferrochelatase genes in Arabidopsis in different tissues and under stress conditions reveals their different roles in haem biosynthesis
The Arabidopsis thaliana genome has two genes (AtFC-I and AtFC-II), encoding ferrochelatase, the terminal enzyme of haem… 
1998
1998
Alternative modes of substrate distortion in enzyme and antibody catalyzed ferrochelation reactions.
Both an antibody that catalyzes metal insertion into porphyrins and the corresponding enzyme, ferrochelatase, are shown by… 
Highly Cited
1994
Highly Cited
1994
Isolation of a cDNA encoding chloroplast ferrochelatase from Arabidopsis thaliana by functional complementation of a yeast mutant.
1994
1994
Site-directed mutagenesis of human ferrochelatase: identification of histidine-263 as a binding site for metal ions.
1984
1984
Effect of sulfhydryl group modification on the activity of bovine ferrochelatase.
Highly Cited
1981
Highly Cited
1981
Rat liver ferrochelatase. Purification, properties, and stimulation by fatty acids.
Highly Cited
1969
Highly Cited
1969
The structural organization of haem synthesis in rat liver mitochondria.
1. Anaerobic conditions are normally necessary for incorporation of iron into haems and only ferrous iron is used. After addition… 
Highly Cited
1967
Highly Cited
1967
Studies on ferrochelatase. The effects of thiols and other factors on the determination of activity.
1. Haems are unstable under aerobic conditions in the presence of thiols, which are used to activate the ferrochelatase enzyme… 
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