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ferrochelatase activity

Known as: protoheme ferro-lyase activity, protoheme ferro-lyase (protoporphyrin-forming), iron chelatase activity 
Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. [EC:4.99.1.1, RHEA:22587]
National Institutes of Health

Papers overview

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Highly Cited
2001
Highly Cited
2001
Protoporphyrin IX is the last common intermediate of tetrapyrrole biosynthesis. The chelation of a Mg2+ ion by magnesium… Expand
Highly Cited
1999
Highly Cited
1999
Abstract. The synthesis of tetrapyrroles is regulated in anticipation of rhythmic changes in environmental conditions such as… Expand
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Highly Cited
1995
Highly Cited
1995
To investigate the role of the iron-sulphur cluster in mammalian ferrochelatases, the terminal enzyme of the haem biosynthetic… Expand
Highly Cited
1990
Highly Cited
1990
Erythropoietic protoporphyria (EPP) is associated with a deficiency of protohaem ferrolyase. We have used a novel assay for this… Expand
1988
1988
We describe a new rapid, sensitive high-performance liquid-chromatographic (HPLC) method for determining ferrochelatase (EC 4.99… Expand
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Highly Cited
1978
Highly Cited
1978
Continuous prolonged exposure to sodium arsenate at 20, 40, or 85 ppm in the drinking water resulted in depression of hepatic… Expand
Highly Cited
1977
Highly Cited
1977
Erythroid ferrochelatase activity has been studied in the normoblasts of patients with porphyria variegata and protoporphyria… Expand
Highly Cited
1977
Highly Cited
1977
The activity of heme synthetase, which catalyzes the chelation of ferrous iron to protoporphyrin to form heme, is deficient in… Expand
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Highly Cited
1975
Highly Cited
1975
In two patients with protoporphyria the enzymatic synthesis of aminolevulinic acid and prophobilinogen in erythroid tissue was… Expand
1973
1973
Abstract Characteristics of the reaction of iron with porphyrin have been studied in aqueous solution in the absence of cellular… Expand