ferrochelatase activity

Known as: protoheme ferro-lyase activity, protoheme ferro-lyase (protoporphyrin-forming), iron chelatase activity 
Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. [EC:4.99.1.1, RHEA:22587]
National Institutes of Health

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Topic mentions per year

1963-2017
051019632017

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2001
2001
Protoporphyrin IX is the last common intermediate of tetrapyrrole biosynthesis. The chelation of a Mg2+ ion by magnesium… (More)
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2000
2000
Mammalian ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, catalyzes the insertion of a ferrous ion into… (More)
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1999
1999
The synthesis of tetrapyrroles is regulated in anticipation of rhythmic changes in environmental conditions such as light… (More)
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1998
1998
Protoporphyria is a genetic disorder in which a deficiency of mitochondrial ferrochelatase activity causes accumulation of… (More)
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1991
1991
A viable autosomal recessive mutation (named fch, or ferrochelatase deficiency) causing jaundice and anemia in mice arose in a… (More)
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1987
1987
A rapid, reliable, sensitive and reproducible HPLC method was developed for the assay of ferrochelatase activity in rat liver… (More)
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1984
1984
The mechanism of porphyrin accumulation by tumours is not yet established. If metabolism aids porphyrin elimination, tumours… (More)
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1980
1980
We describe a radiochemical method for measuring ferrochelatase activity in the in vitro incorporation of iron into mesoporphyrin… (More)
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1979
1979
Ferrochelatase deficiency has been shown in both porphyria variegata (PV) and erythropoietic protoporphyria (EPP). It has been… (More)
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1975
1975
In two patients with protoporphyria the enzymatic synthesis of aminolevulinic acid and prophobilinogen in erythroid tissue was… (More)
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