ferrochelatase activity

Known as: protoheme ferro-lyase activity, protoheme ferro-lyase (protoporphyrin-forming), iron chelatase activity

Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. [EC:4.99.1.1, RHEA:22587]

National Institutes of Health

Papers overview

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1999

Ferrochelatase is the terminal enzyme in the heme biosynthesis pathway. Under anaerobic conditions it catalyzes the insertion of…

1992

Cytochrome P450- and heme-destructive effects of the 4-nonyl and 4-dodecyl analogues of 3,5-diethoxycarbonyl-1,4-dihydro-2,4,6…

Review

1989

Review

1989

We studied the porphyrin metabolism of a 7‐year‐old Japanese boy with erythropoietic protoporphyria (EPP) and his family members…

1988

We describe a new rapid, sensitive high-performance liquid-chromatographic (HPLC) method for determining ferrochelatase (EC 4.99…

1982

A radiochemical assay for heme synthase (ferrochelatase) activity is described in this report. The principle of the assay is to…

1980

We describe a radiochemical method for measuring ferrochelatase activity in the in vitro incorporation of iron into mesoporphyrin…

1979

Ferrochelatase deficiency has been shown in both porphyria variegata (PV) and erythropoietic protoporphyria (EPP). It has been…

1975

Experiments have been performed which show that it is possible to regulate heme biosynthesis by regulating ferrochelatase…

1973

1969

Abstract Sideroblastic anemia was found in an elderly man in association with dermal photosensitivity, a greatly increased…