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ferrochelatase activity

Known as: protoheme ferro-lyase activity, protoheme ferro-lyase (protoporphyrin-forming), iron chelatase activity 
Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. [EC:4.99.1.1, RHEA:22587]
National Institutes of Health

Related topics

Related topics

1 relation
FECH gene

Papers overview

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Highly Cited
2001
Highly Cited
2001
Impaired expression of the plastidic ferrochelatase by antisense RNA synthesis leads to a necrotic phenotype of transformed tobacco plants.
Protoporphyrin IX is the last common intermediate of tetrapyrrole biosynthesis. The chelation of a Mg2+ ion by magnesium… 
Highly Cited
1999
Highly Cited
1999
Expression studies in tetrapyrrole biosynthesis: inverse maxima of magnesium chelatase and ferrochelatase activity during cyclic photoperiods
Abstract. The synthesis of tetrapyrroles is regulated in anticipation of rhythmic changes in environmental conditions such as… 
Highly Cited
1995
Highly Cited
1995
Nitric oxide-mediated inactivation of mammalian ferrochelatase in vivo and in vitro: possible involvement of the iron-sulphur cluster of the enzyme.
To investigate the role of the iron-sulphur cluster in mammalian ferrochelatases, the terminal enzyme of the haem biosynthetic… 
Highly Cited
1990
Highly Cited
1990
Genetic heterogeneity in erythropoietic protoporphyria: a study of the enzymatic defect in nine affected families.
Erythropoietic protoporphyria (EPP) is associated with a deficiency of protohaem ferrolyase. We have used a novel assay for this… 
1988
1988
Ferrochelatase activity in human lymphocytes, as quantified by a new high-performance liquid-chromatographic method.
We describe a new rapid, sensitive high-performance liquid-chromatographic (HPLC) method for determining ferrochelatase (EC 4.99… 
1988
1988
Heme arginate treatment for myelodysplastic syndromes.
Highly Cited
1978
Highly Cited
1978
Altered regulation of mammalian hepatic heme biosynthesis and urinary porphyrin excretion during prolonged exposure to sodium arsenate.
Highly Cited
1977
Highly Cited
1977
Reduced Ferrochelatase Activity: a Defect Common to Porphyria Variegata and Protoporphyria
Erythroid ferrochelatase activity has been studied in the normoblasts of patients with porphyria variegata and protoporphyria… 
Highly Cited
1975
Highly Cited
1975
Diminished erythroid ferrochelatase activity in protoporphyria.
In two patients with protoporphyria the enzymatic synthesis of aminolevulinic acid and prophobilinogen in erythroid tissue was… 
1969
1969
Sideroblastic anemia with dermal photosensitivity and greatly increased erythrocyte protoporphyrin.
Abstract Sideroblastic anemia was found in an elderly man in association with dermal photosensitivity, a greatly increased… 
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