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ferrochelatase activity

Known as: protoheme ferro-lyase activity, protoheme ferro-lyase (protoporphyrin-forming), iron chelatase activity 
Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX. [EC:4.99.1.1, RHEA:22587]
National Institutes of Health

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2001
2001
Protoporphyrin IX is the last common intermediate of tetrapyrrole biosynthesis. The chelation of a Mg2+ ion by magnesium… Expand
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Highly Cited
1999
Highly Cited
1999
Abstract. The synthesis of tetrapyrroles is regulated in anticipation of rhythmic changes in environmental conditions such as… Expand
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1995
1995
To investigate the role of the iron-sulphur cluster in mammalian ferrochelatases, the terminal enzyme of the haem biosynthetic… Expand
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1990
1990
Erythropoietic protoporphyria (EPP) is associated with a deficiency of protohaem ferrolyase. We have used a novel assay for this… Expand
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1988
1988
We describe a new rapid, sensitive high-performance liquid-chromatographic (HPLC) method for determining ferrochelatase (EC 4.99… Expand
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1985
1985
The ferrochelatase-reducing activity and cytochrome P-450- and heme-destructive effects of a variety of analogues of 3,5… Expand
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1977
1977
Erythroid ferrochelatase activity has been studied in the normoblasts of patients with porphyria variegata and protoporphyria… Expand
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1975
1975
In two patients with protoporphyria the enzymatic synthesis of aminolevulinic acid and prophobilinogen in erythroid tissue was… Expand
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1973
1973
Abstract Characteristics of the reaction of iron with porphyrin have been studied in aqueous solution in the absence of cellular… Expand
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1969
1969
Abstract Sideroblastic anemia was found in an elderly man in association with dermal photosensitivity, a greatly increased… Expand
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