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FD 891

Known as: 9,19-Dioxabicyclo(16.1.0)nonadeca-4,6,12,14-tetraen-8-one, 10-(4,6-dihydroxy-8-methoxy-1,5,7-trimethylnonyl)-2,17-dihydroxy-3,5,7-trimethyl-, FD-891 
National Institutes of Health

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2 relations

Broader (2)

Macrolide AntibioticsMacrolides

Papers overview

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2017
2017
Substrate Recognition by a Dual‐Function P450 Monooxygenase GfsF Involved in FD‐891 Biosynthesis
GfsF is a multifunctional P450 monooxygenase that catalyzes epoxidation and subsequent hydroxylation in the biosynthesis of… 
2016
2016
Parallel Post‐Polyketide Synthase Modification Mechanism Involved in FD‐891 Biosynthesis in Streptomyces graminofaciens A‐8890
To isolate a key polyketide biosynthetic intermediate for the 16‐membered macrolide FD‐891 (1), we inactivated two biosynthetic… 
2014
2014
A concise and unified strategy for synthesis of the C1-C18 macrolactone fragments of FD-891, FD-892 and their analogues: formal total synthesis of FD-891.
A concise and unified strategy for the synthesis of C1-C18 macrolactone fragments of FD-891 and FD-892 as well as their analogues… 
2012
2012
Stereoselective total synthesis of FD-891.
FD-891, a structurally unique 16-membered macrolide having anticancer activity, was synthesized according to a strategy employing… 
2009
2009
The cytotoxic macrolide FD-891 induces caspase-8-dependent mitochondrial release of cytochrome c and subsequent apoptosis in human leukemia Jurkat cells
The 16-membered macrolide FD-891 exerts cytotoxicity toward several cancer cell lines. In this study, we showed that FD-891… 
2006
2006
Stereoselective synthesis of the cytotoxic macrolide FD-891.
[reaction: see text] A total synthesis of the naturally occurring, cytotoxic macrolide FD-891 is described. Three fragments were… 
2000
2000
FD‐891, a structural analogue of concanamycin A that does not affect vacuolar acidification or perforin activity, yet potently prevents cytotoxic T lymphocyte‐mediated cytotoxicity through the…
FD-891 belongs to a group of 18-membered macrolides, and is a structural analogue of a specific inhibitor of vacuolar type H… 
1994
1994
Isolation and characterization of new 18-membered macrolides FD-891 and FD-892.
New 18-membered macrolides FD-891 and FD-892 were discovered from the fermentation broth of Streptomyces graminofaciens A-8890… 
1994
1994
Structures of new 18-membered macrolides FD-891 and FD-892.
Structures of FD-891 and FD-892 were determined by extensive NMR spectral analysis as shown in Fig. 1. They belong to such 18… 
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