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Efficient enantioselective reduction of ketones with Daucus carota root.
A novel and efficient reduction of various prochiral ketones such as acetopehones, alpha-azido aryl ketones, beta-ketoesters, and aliphatic acyclic and cyclic ketones with moderate to excellent chemical yield was achieved by using Daucus carota, root plant cells under extremely mild and environmentally benign conditions in aqueous medium. Expand
A novel TMSI-mediated synthesis of Hantzsch 1,4-dihydropyridines at ambient temperature
The synthesis of various substituted Hantzsch 1,4-dihydropyridines has been achieved using the classical Hantzsch procedure and modified Hantzsch conditions for the first time at room temperature inExpand
Plant HDAC inhibitor chrysin arrest cell growth and induce p21WAF1 by altering chromatin of STAT response element in A375 cells
The results support an unexpected action of chrysin on the chromatin organization of p21WAF1 promoter through histone methylation and hyper-acetylation and proposes previously unknown sequence specific chromatin modulations in the STAT responsive elements for regulating cell cycle progression negatively. Expand
Rugulactone derivatives act as inhibitors of NF-κB activation and modulates the transcription of NF-κB dependent genes in MDA-MB-231cells.
The apoptotic inducing nature of these compounds was confirmed by activation of PARP protein, a protein that plays a key role in DNA damage and repair pathways, and among all compounds of this series 3g is the most potent compound and can be used for further studies. Expand
Three-component coupling reactions in ionic liquids: One-pot synthesis of isoxazolidines☆
1-Butyl-3-methylimidazolium based ionic liquids are found to accelerate significantly the intermolecular 1,3-dipolar cycloaddition of nitrones derived in situ from aldehydes and phenyl hydroxylamine,Expand
Phosphane‐Catalyzed Knoevenagel Condensation: A Facile Synthesis of α‐Cyanoacrylates and α‐Cyanoacrylonitriles
Triphenylphosphane (TPP) has been utilized as a novel and efficient catalyst for the Knoevenagel condensation of aldehydes with acidic methylene compounds such as ethyl cyanoacetate and malononitrileExpand
InCl3-Catalysed Conjugate Addition of Indoles with Electron-Deficient Olefins
Indole and 2-methylindole undergo conjugate addition with electron-deficient olefins in the presence of a catalytic amount of InCl3 at ambient temperature to afford the corresponding Michael adductsExpand
Lithium Perchlorate Catalyzed Reactions of Indoles: An Expeditious Synthesis of Bis(indolyl)methanes
Lithium perchlorate is found to catalyze efficiently the electrophilic substitution reactions of indoles with aldehydes and ketones in diethyl ether to afford the corresponding bis(indolyl)methanesExpand