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FCGR2C gene

Known as: Fc Fragment of IgG, Low Affinity IIc, Receptor for (CD32) (Gene/Pseudogene) Gene, CD32C, hFcRII-C 
This gene is involved in the initiation of host immune responses against pathogens and phagocytosis.
National Institutes of Health

Related topics

Related topics

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CD32 AntigensFCGR2A geneFCGR2A protein, humanFCGR2A wt Allele

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FCGR2C wt Allele

Papers overview

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2019
2019
Fc Gamma Receptor Polymorphisms Modulated the Vaccine Effect on HIV-1 Risk in the HVTN 505 HIV Vaccine Trial
By analyzing data from the HVTN 505 efficacy trial of a DNA/recombinant adenovirus 5 (rAd5) vaccine regimen, we found that host… 
2017
2017
Nonclassical FCGR2C haplotype is associated with protection from red blood cell alloimmunization in sickle cell disease.
Red blood cell (RBC) transfusions are of vital importance in patients with sickle cell disease (SCD). However, a major… 
Highly Cited
2016
Highly Cited
2016
Fc-gamma receptor polymorphisms differentially influence susceptibility to systemic lupus erythematosus and lupus nephritis.
OBJECTIVE To determine relevant Fc-gamma receptor (FcγR) polymorphisms in relation to susceptibility to SLE and LN, and to… 
2016
2016
FCGR Polymorphisms Influence Response to IL2 in Metastatic Renal Cell Carcinoma
Purpose: Fc-gamma receptors (FCGRs) are expressed on immune cells, bind to antibodies, and trigger antibody-induced cell-mediated… 
2016
2016
FCGR2C Polymorphisms Associated with HIV-1 Vaccine Protection Are Linked to Altered Gene Expression of Fc-γ Receptors in Human B Cells
The phase III Thai RV144 vaccine trial showed an estimated vaccine efficacy (VE) to prevent HIV-1 infection of 31.2%, which has… 
2015
2015
Polymorphism of FCGR2A, FCGR2C, and FCGR3B Genes in the Pathogenesis of Sarcoidosis.
We have previously presented evidence that the polymorphism of the FCGR3A gene, encoding the receptor for Fc fragment of… 
2015
2015
Variability at the FCGR locus: characterization in Black South Africans and evidence for ethnic variation in and out of Africa
This study set out to comprehensively investigate all known functional FcγR variants in South African Black and Caucasian… 
2012
2012
FCGR2C genotyping by pyrosequencing reveals linkage disequilibrium with FCGR3A V158F and FCGR2A H131R polymorphisms in a Caucasian population
The FCGR3A-V158F and FCGR2A-H131R polymorphisms are associated with clinical responses to therapeutic mAbs and with immune… 
Highly Cited
2007
Highly Cited
2007
Monoclonal antibodies capable of discriminating the human inhibitory Fcγ‐receptor IIB (CD32B) from the activating Fcγ‐receptor IIA (CD32A): biochemical, biological and functional characterization
Human CD32B (FcγRIIB), the low‐affinity inhibitory Fcγ receptor (FcγR), is highly homologous in its extracellular domain to CD32A… 
2004
2004
Variation in human FCGR2C gene copy number
Genetic variation in Fcy receptors, which bind the Fc portion of IgG, may be important in disorders of host defense and systemic… 
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