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Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10
BACKGROUND Most of the effort directed at understanding the role infections have in preventing allergy has focused on bacteria and viruses and their ability to divert the immune system towardsExpand
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A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants.
BACKGROUND The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studiedExpand
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Low Interleukin-12 Activity in Severe Plasmodium falciparum Malaria
ABSTRACT We compared interleukin-12 (IL-12) and other cytokine activities during and after an acute clinical episode in a matched-pair case-control study of young African children who presented withExpand
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Genetic Diversity and Protective Efficacy of the RTS,S/AS01 Malaria Vaccine.
BACKGROUND The RTS,S/AS01 vaccine targets the circumsporozoite protein of Plasmodium falciparum and has partial protective efficacy against clinical and severe malaria disease in infants andExpand
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Phase 1 Trials of rVSV Ebola Vaccine in Africa and Europe.
BACKGROUND The replication-competent recombinant vesicular stomatitis virus (rVSV)-based vaccine expressing a Zaire ebolavirus (ZEBOV) glycoprotein was selected for rapid safety and immunogenicityExpand
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Virulence factors and genotypes of Staphylococcus aureus from infection and carriage in Gabon.
Staphylococcus aureus isolates from developed countries have been extensively analyzed with respect to their virulence patterns and clonal relatedness but there is only sparse information on theExpand
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Interferon-gamma responses are associated with resistance to reinfection with Plasmodium falciparum in young African children.
The contribution of T cell-mediated responses was studied with regard to resistance to reinfection in groups of Gabonese children participating in a prospective study of severe and mild malaria dueExpand
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Merozoite surface antigen 1 and 2 genotypes and rosetting of Plasmodium falciparum in severe and mild malaria in Lambaréné, Gabon.
We present a case-control study to investigate the distribution of Plasmodium falciparum genotypes in patients with severe and mild malaria. We compared clinical and parasitological data with theExpand
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The role of red blood cell polymorphisms in resistance and susceptibility to malaria.
In regions highly endemic for Plasmodium falciparum malaria, red cell polymorphisms that confer resistance to severe disease are widespread. Sickle cell trait, alpha-thalassemia, glucose-6-phosphateExpand
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