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FCE 22891

Known as: FCE-22891 
National Institutes of Health

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1 relation

Broader (1)

Lactams

Papers overview

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1993
1993
The effect of FCE 22891, a new oral penem, on faecal flora anaerobes and their fermentation end products in patients with chronic obstructive pulmonary disease
SummaryThe influence of FCE 22891 on the faecal flora was investigated in 11 patients with an acute exacerbation of chronic… 
1992
1992
Pharmacokinetics of [14C]FCE 22891, a penem antibiotic, following oral administration to healthy volunteers
FCE 22891 is a prodrug of the penem antibiotic FCE 22101 and is suitable for oral administration. The pharmacokinetics of FCE… 
1992
1992
Pharmacokinetics and metabolism of FCE 22101 following its administration as the oral pro-drug FCE 22891.
Ten healthy male volunteers who had previously received both intramuscular and intravenous doses of FCE 22101 received a single… 
1990
1990
Pharmacokinetics in healthy subjects of FCE 22101 and its acetoxymethyl ester, FCE 22891: effect of co-administration of imipenem/cilastatin on the renal metabolism of FCE 22101.
The pharmacokinetics of FCE 22101 were studied in eight healthy male subjects who received FCE 22101 intravenously alone or… 
1990
1990
The disposition and urinary metabolism of 14C-labelled FCE 22891, a pro-drug of FCE 22101, in animals.
[2-14C]FCE 22891 was given orally and intravenously to the rat, orally to the dog and monkey. Radioactivity was eliminated by… 
1990
1990
Rapid hydrolysis in vivo in man of FCE 22891, the orally absorbed ester of FCE 22101.
Detection du FCE 22891, ester de l'antibiotique FCE 22101, apres administration orale a des volontaires de ce promedicament. Le… 
Review
1989
Review
1989
Synthesis and antimicrobial spectrum of FCE 22101 and its orally available ester FCE 22891.
The most efficient routes for the synthesis of FCE 22101, a penem antibiotic characterized by a carbamoyloxymethyl sidechain at C… 
1989
1989
Toxicological profile of FCE 22101 and its orally available ester FCE 22891.
LD50 values of FCE 22101 iv were 3872 mg/kg and 4392 mg/kg in male and female mice, and 2000 mg/kg and 2201 mg/kg in male and… 
1989
1989
Activity of FCE 22891 compared with cefuroxime axetil and cefixime in pulmonary and subcutaneous infections in mice.
The therapeutic activity of FCE 22891 was compared with that of two new oral cephalosporins, cefuroxime axetil and cefixime… 
1989
1989
FCE 22101 and FCE 22891: in-vitro antibacterial activity at concentrations simulating human plasma levels following intravenous, intramuscular and oral administration.
The plasma concentrations of FCE 22101 observed following slow intravenous infusions (1 and 4 h), intramuscular injection and… 
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