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Drug metabolism and disposition in children
TLDR
Key factors undergoing maturational changes accounting for differences in drug metabolism and disposition in the pediatric population compared with adults are reviewed and it would be important to generate information on the developmental aspects of renal P‐glycoprotein and of other renal transporters as done and still being done with the different isozymes involved indrug metabolism. Expand
Differences in absorption, distribution, metabolism and excretion of xenobiotics between the paediatric and adult populations
TLDR
Key factors undergoing maturational changes accounting for differences in drug metabolism and disposition in the paediatric population compared with adults are reviewed and include glomerular filtration and tubular secretion. Expand
Absorption, distribution, metabolism and excretion of [14C]levocetirizine, the R enantiomer of cetirizine, in healthy volunteers
TLDR
There was no evidence of chiral inversion of levocetirizine in humans, consistent with that obtained in preclinical studies. Expand
A sensitive procedure for the quantitation of free and N-(2-hydroxypropyl) methacrylamide polymer-bound doxorubicin (PK1) and some of its metabolites, 13-dihydrodoxorubicin, 13-dihydrodoxorubicinone
A high-performance liquid chromatographic assay has been developed and validated for the determination in plasma and urine of doxorubicin (DXR) and some of its metabolites released in vivo from anExpand
Comparative pharmacokinetics and metabolism of levetiracetam, a new anti-epileptic agent, in mouse, rat, rabbit and dog
TLDR
In the rat, the enzyme system hydrolysing levetiracetam is not induced by phenobarbital, at least under the experimental conditions used herein, whereas the enzymeSystem(s) involved in the other metabolic pathways is induced. Expand
Pharmacokinetics of theophylline: a dose-range study.
TLDR
After single oral administration, elimination of theophylline followed first-order kinetics in the range of doses investigated and some impairment of demethylation to 3-methylxanthine was observed in two subjects, however the percentage of the Flower and its major metabolites excreted in urine was constant for all the four doses. Expand
Absorption, disposition and preliminary metabolic pathway of 14C-rifabutin in animals and man.
TLDR
Rifabutin was the predominant compound circulating in plasma at the first sampling times, but significant levels of 31-OH rifAButin were detected up to 8-24 h in all species studied, and 25-O-deacetyl rifabUTin was detected only in rat and man. Expand
Stereoselective and species-dependent kinetics of reboxetine in mouse and rat.
TLDR
Evidence is provided for the higher bioavailability and/or lower clearance of both enantiomers in mice than in rats, and for a higher penetration of bothEnantiomers into mouse brain compared to rat brain. Expand
Pharmacokinetics and metabolism of 14C-levetiracetam, a new antiepileptic agent, in healthy volunteers
TLDR
The absorption, disposition and metabolism of levetiracetam, a new antiepileptic drug, have been investigated after a single oral dose of the 14C-labelled molecule administered to male healthy volunteers and there was no evidence of chiral inversion. Expand
Involvement of enzymes other than CYPs in the oxidative metabolism of xenobiotics
TLDR
The contribution of non-CYP oxidative enzymes to the overall metabolism of xenobiotics is underestimated, as most investigations of drug metabolism in discovery and lead optimisation are performed using in vitro test systems optimised for CYP activity. Expand
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