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FBXO5 wt Allele

Known as: EMI1, Xenopus, Homolog of Gene, FBX5, Fbxo31 
Human FBXO5 wild-type allele is located within 6q25-q26 and is approximately 13 kb in length. This allele, which encodes F-box only protein 5, is… Expand
National Institutes of Health

Related topics

Related topics

3 relations
Cell Cycle ControlCell Cycle ProgressionNegative Regulation of Mitosis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
A Dynamical Framework for the All-or-None G1/S Transition
Summary The transition from G1 into DNA replication (S phase) is an emergent behavior resulting from dynamic and complex… Expand
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Highly Cited
2013
Highly Cited
2013
Emi1 preferentially inhibits ubiquitin chain elongation by the anaphase promoting complex
The anaphase-promoting complex (APC) is the crucial ubiquitin ligase targeting the regulatory machinery of the cell cycle. Emi1… Expand
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2013
2013
The Centrosomal E3 Ubiquitin Ligase FBXO31-SCF Regulates Neuronal Morphogenesis and Migration
Neuronal development requires proper migration, polarization and establishment of axons and dendrites. Growing evidence… Expand
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Highly Cited
2009
Highly Cited
2009
F-Box Protein FBXO31 Mediates Cyclin D1 Degradation to Induce G1 Arrest Following DNA Damage
In response to DNA damage, eukaryotic cells initiate a complex signalling pathway, termed the DNA damage response (DDR), which… Expand
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2008
2008
Emi1 protein accumulation implicates misregulation of the anaphase promoting complex/cyclosome pathway in ovarian clear cell carcinoma
Clear cell carcinoma is a clinically and pathologically distinct entity among surface epithelial ovarian neoplasms, recognized… Expand
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Highly Cited
2006
Highly Cited
2006
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor.
The periodic destruction of mitotic cyclins is triggered by the activation of the anaphase-promoting complex/cyclosome (APC/C) in… Expand
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Highly Cited
2005
Highly Cited
2005
FBXO31 is the chromosome 16q24.3 senescence gene, a candidate breast tumor suppressor, and a component of an SCF complex.
A BAC located in the 16q24.3 breast cancer loss of heterozygosity region was previously shown to restore cellular senescence when… Expand
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Highly Cited
2002
Highly Cited
2002
E2F-dependent accumulation of hEmi1 regulates S phase entry by inhibiting APCCdh1
Emi1 promotes mitotic entry in Xenopus laevis embryos by inhibiting the APCCdc20 ubiquitination complex to allow accumulation of… Expand
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Highly Cited
2001
Highly Cited
2001
Emi1 Is a Mitotic Regulator that Interacts with Cdc20 and Inhibits the Anaphase Promoting Complex
We have discovered an early mitotic inhibitor, Emi1, which regulates mitosis by inhibiting the anaphase promoting complex… Expand
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Highly Cited
2001
Highly Cited
2001
Emi1 regulates the anaphase-promoting complex by a different mechanism than Mad2 proteins.
The anaphase-promoting complex/cyclosome (APC) ubiquitin ligase is activated by Cdc20 and Cdh1 and inhibited by Mad2 and the… Expand
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