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ATM and related protein kinases: safeguarding genome integrity
  • Y. Shiloh
  • Biology, Medicine
  • Nature Reviews Cancer
  • 1 March 2003
Maintenance of genome stability is essential for avoiding the passage to neoplasia. The DNA-damage response — a cornerstone of genome stability — occurs by a swift transduction of the DNA-damageExpand
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ATM and ATR Substrate Analysis Reveals Extensive Protein Networks Responsive to DNA Damage
Cellular responses to DNA damage are mediated by a number of protein kinases, including ATM (ataxia telangiectasia mutated) and ATR (ATM and Rad3-related). The outlines of the signal transductionExpand
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The ATM protein kinase: regulating the cellular response to genotoxic stress, and more.
The protein kinase ataxia-telangiectasia mutated (ATM) is best known for its role as an apical activator of the DNA damage response in the face of DNA double-strand breaks (DSBs). Following inductionExpand
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Requirement of the MRN complex for ATM activation by DNA damage
The ATM protein kinase is a primary activator of the cellular response to DNA double‐strand breaks (DSBs). In response to DSBs, ATM is activated and phosphorylates key players in various branches ofExpand
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A single ataxia telangiectasia gene with a product similar to PI-3 kinase.
A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is characterized by cerebellarExpand
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Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro.
The protein kinase Chk2, the mammalian homolog of the budding yeast Rad53 and fission yeast Cds1 checkpoint kinases, is phosphorylated and activated in response to DNA damage by ionizing radiationExpand
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Enhanced phosphorylation of p53 by ATM in response to DNA damage.
The ATM protein, encoded by the gene responsible for the human genetic disorder ataxia telangiectasia (A-T), regulates several cellular responses to DNA breaks. ATM shares a phosphoinositideExpand
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ATM signaling facilitates repair of DNA double-strand breaks associated with heterochromatin.
Ataxia Telangiectasia Mutated (ATM) signaling is essential for the repair of a subset of DNA double-strand breaks (DSBs); however, its precise role is unclear. Here, we show that < or =25% of DSBsExpand
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Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
The cellular DNA-damage response is a signaling network that is vigorously activated by cytotoxic DNA lesions, such as double-strand breaks (DSBs). The DSB response is mobilized by the nuclearExpand
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Atm-Deficient Mice: A Paradigm of Ataxia Telangiectasia
A murine model of ataxia telangiectasia was created by disrupting the Atm locus via gene targeting. Mice homozygous for the disrupted Atm allele displayed growth retardation, neurologic dysfunction,Expand
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