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Eukaryotic Initiation Factor-4A

Known as: Eukaryotic Initiation Factor-4A [Chemical/Ingredient], Initiation Factor-4A, Eukaryotic, Peptide Initiation Factor EIF 4A 
A component of eukaryotic initiation factor 4F that as an RNA helicase involved in unwinding the secondary structure of the 5' UNTRANSLATED REGION of… Expand
National Institutes of Health

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12 relations
EIF4A1 geneIn BloodProcess of secretionagonists
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Narrower (3)

Eukaryotic Initiation Factor-4A1Eukaryotic Initiation Factor-4A2Eukaryotic Initiation Factor-4A3

Papers overview

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Highly Cited
2008
Highly Cited
2008
Translational control by a small RNA: dendritic BC1 RNA targets the eukaryotic initiation factor 4A helicase mechanism.
Translational repressors, increasing evidence suggests, participate in the regulation of protein synthesis at the synapse, thus… Expand
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Highly Cited
1996
Highly Cited
1996
Canonical eukaryotic initiation factors determine initiation of translation by internal ribosomal entry.
Translation of picornavirus RNA is initiated after ribosomal binding to an internal ribosomal entry site (IRES) within the 5… Expand
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Highly Cited
1995
Highly Cited
1995
Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.
An important aspect of the regulation of gene expression is the modulation of translation rates in response to growth factors… Expand
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Highly Cited
1994
Highly Cited
1994
Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.
Eukaryotic translation initiation factor-4A (eIF-4A) plays a critical role in binding of eukaryotic mRNAs to ribosomes. It has… Expand
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Highly Cited
1993
Highly Cited
1993
The HRIGRXXR region of the DEAD box RNA helicase eukaryotic translation initiation factor 4A is required for RNA binding and ATP hydrolysis.
eIF-4A is a eukaryotic translation initiation factor that is required for mRNA binding to ribosomes. It exhibits single-stranded… Expand
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Highly Cited
1993
Highly Cited
1993
The p46 subunit of eukaryotic initiation factor (eIF)-4F exchanges with eIF-4A.
The p46 subunit of eukaryotic initiation factor (eIF)-4F purified from rabbit reticulocyte lysate has previously been found to be… Expand
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Highly Cited
1992
Highly Cited
1992
Mutational analysis of a DEAD box RNA helicase: the mammalian translation initiation factor eIF-4A.
eIF-4A is a translation initiation factor that exhibits bidirectional RNA unwinding activity in vitro in the presence of another… Expand
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Highly Cited
1990
Highly Cited
1990
Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.
The mechanism of ribosome binding to eucaryotic mRNAs is not well understood, but it requires the participation of eucaryotic… Expand
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Highly Cited
1985
Highly Cited
1985
ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.
Interaction of protein synthesis initiation factors with mRNA has been studied in order to characterize early events in the… Expand
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1983
1983
Involvement of eukaryotic initiation factor 4A in the cap recognition process.
Antibodies against eukaryotic initiation factor 4A (eIF-4A) were used to study the involvement of this factor in recognizing the… Expand
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