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Eukaryotic Initiation Factor-3

Known as: Eukaryotic Peptide Initiation Factor 3, EIF-3, Peptide Initiation Factor EIF-3 
A multisubunit eukaryotic initiation factor that contains at least 8 distinct polypeptides. It plays a role in recycling of ribosomal subunits to the… Expand
National Institutes of Health

Related topics

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19 relations

Narrower (7)

EIF3A protein, humanEukaryotic Initiation Factor-3, Subunit 3Eukaryotic Initiation Factor-3, Subunit 4Eukaryotic Initiation Factor-3, Subunit 8
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EIF3E geneEIF3E wt AlleleIn BloodProcess of secretion
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Papers overview

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Highly Cited
2009
Highly Cited
2009
Robust heat shock induces eIF2α-phosphorylation-independent assembly of stress granules containing eIF3 and 40S ribosomal subunits in budding yeast, Saccharomyces cerevisiae
Environmental stresses inducing translation arrest are accompanied by the deposition of translational components into stress… Expand
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Highly Cited
2008
Highly Cited
2008
Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3
The eukaryotic initiation factor 3 (eIF3) plays an important role in translation initiation, acting as a docking site for several… Expand
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Review
2007
Review
2007
Mammalian stress granules and processing bodies.
The packaging of cytoplasmic mRNA into discrete RNA granules regulates gene expression by delaying the translation of specific… Expand
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Highly Cited
2005
Highly Cited
2005
mTOR and S6K1 Mediate Assembly of the Translation Preinitiation Complex through Dynamic Protein Interchange and Ordered Phosphorylation Events
In response to nutrients, energy sufficiency, hormones, and mitogenic agents, S6K1 phosphorylates several targets linked to… Expand
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Highly Cited
2005
Highly Cited
2005
PCI proteins eIF3e and eIF3m define distinct translation initiation factor 3 complexes
BackgroundPCI/MPN domain protein complexes comprise the 19S proteasome lid, the COP9 signalosome (CSN), and eukaryotic… Expand
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Highly Cited
2005
Highly Cited
2005
Structural Roles for Human Translation Factor eIF3 in Initiation of Protein Synthesis
Protein synthesis in mammalian cells requires initiation factor eIF3, a ∼750-kilodalton complex that controls assembly of 40S… Expand
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Highly Cited
2003
Highly Cited
2003
Ribosome Loading onto the mRNA Cap Is Driven by Conformational Coupling between eIF4G and eIF4E
The eukaryotic initiation factor 4G (eIF4G) is the core of a multicomponent switch controlling gene expression at the level of… Expand
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Highly Cited
2000
Highly Cited
2000
A new pathway of translational regulation mediated by eukaryotic initiation factor 3
We report a new pathway of translation regulation that may operate in interferon‐treated or virus‐infected mammalian cells. This… Expand
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Highly Cited
1998
Highly Cited
1998
Specific Interaction of Eukaryotic Translation Initiation Factor 3 with the 5′ Nontranslated Regions of Hepatitis C Virus and Classical Swine Fever Virus RNAs
ABSTRACT Translation of hepatitis C virus (HCV) and classical swine fever virus (CSFV) RNAs is initiated by cap-independent… Expand
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Highly Cited
1997
Highly Cited
1997
Structure of cDNAs Encoding Human Eukaryotic Initiation Factor 3 Subunits
The mammalian translation initiation factor 3 (eIF3), is a multiprotein complex of ∼600 kDa that binds to the 40 S ribosome and… Expand
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