• Publications
  • Influence
Evidence for a clade of nematodes, arthropods and other moulting animals
TLDR
The results suggest that ecdysis (moulting) arose once and support the idea of a new clade, Ecdysozoa, containing moulting animals: arthropods, tardigrades, onychophorans, nematodes, Nematomorphs, kinor-hynchs and priapulids.
Horizontal gene transfer among genomes: the complexity hypothesis.
TLDR
It is proposed that a major factor in the more frequent horizontal transfer of operational genes is that informational genes are typically members of large, complex systems, whereas operational genes are not, thereby making horizontalTransfer of informational gene products less probable (the complexity hypothesis).
Reconstructing evolutionary trees from DNA and protein sequences: paralinear distances.
  • J. Lake
  • Biology
    Proceedings of the National Academy of Sciences…
  • 15 February 1994
TLDR
The "origin of the eukaryotes" has been investigated by the analysis of elongation factor Tu sequences with a variety of sequence alignments, and it has been found that the order in which sequences are pairwise aligned strongly determines the topology which is reconstructed by paralinear distances.
Genomic evidence for two functionally distinct gene classes.
TLDR
Comparisons of the entire set of Methanococcus jannaschii genes with their orthologs from Escherichia coli, Synechocystis 6803, and the yeast Saccharomyces cerevisiae show that prokaryotic genomes consist of two different groups of genes.
The ring of life provides evidence for a genome fusion origin of eukaryotes
TLDR
The general outline of the tree of life is determined using complete genome data from representative prokaryotes and eukaryote and a new genome analysis method that makes it possible to reconstruct ancient genome fusions and phylogenetic trees.
A rate-independent technique for analysis of nucleic acid sequences: evolutionary parsimony.
  • J. Lake
  • Biology
    Molecular biology and evolution
  • 1 March 1987
TLDR
The method of evolutionary parsimony accurately predicts the tree, even when substitution rates differ greatly in neighboring peripheral branches (conditions under which parsimony will consistently fail), as the number of substitutions in peripheral branches becomes fewer, the parsimony and the evolutionary-parsimony solutions converge.
Evidence that eukaryotes and eocyte prokaryotes are immediate relatives.
TLDR
The eocytes are the closest surviving relatives (sister taxon) of the eukaryotes, and the related (paralogous) genes encoding elongation factor EF-2 and initiation factor IF-2 also lacked the 11-amino acid insert.
Origin of the eukaryotic nucleus determined by rate-invariant analysis of rRNA sequences
  • J. Lake
  • Biology
    Nature
  • 1 January 1988
TLDR
Using evolutionary parsimony, a newly developed rate-invariant treeing algorithm, the eukaryotic ribosomal rRNA genes are shown to have evolved from the eocytes, a group of extremely thermophilic, sulphur-metabolizing, anucleate cells that probably lacked nuclei, metabolized sulphur and lived at near-boiling temperatures.
Eocytes: a new ribosome structure indicates a kingdom with a close relationship to eukaryotes.
TLDR
It is suggested that an appropriate kingdom name for this group of ribosomes from eubacteria, archaebacteria, eukaryotes, and a group of sulfur-dependent bacteria would be the Eocyta.
Horizontal gene transfer accelerates genome innovation and evolution.
TLDR
Analysis of 20,000 genes contained in eight free-living prokaryotic genomes indicates that HGT occurs among organisms that share similar factors, including genome size, genome G/C composition, carbon utilization, and oxygen tolerance.
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