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The enzymes, regulation, and genetics of bile acid synthesis.
- D. Russell
- BiologyAnnual review of biochemistry
- 28 November 2003
The synthesis and excretion of bile acids comprise the major pathway of cholesterol catabolism in mammals and causes a spectrum of human disease; this ranges from liver failure in early childhood to progressive neuropathy in adults.
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
EPAS1 expression is limited to the endothelium of mouse embryos and is capable of specifically activating the transcription of the endothelial tyrosine kinase gene Tie-2, raising the possibility that EPAS1 may represent an important regulator of vascularization, perhaps involving the regulation of endothelial cell gene expression in response to hypoxia.
Clinical importance of the cytochromes P450
A comprehensive classification system for lipids11 The evaluation of this manuscript was handled by the former Editor-in-Chief Trudy Forte. Published, JLR Papers in Press, February 16, 2005. DOI…
A comprehensive classification of lipids with a common platform that is compatible with informatics requirements has been developed to deal with the massive amounts of data that will be generated by the lipid community.
cDNA cloning of cholesterol 24-hydroxylase, a mediator of cholesterol homeostasis in the brain.
- E. Lund, J. Guileyardo, D. Russell
- Biology, ChemistryProceedings of the National Academy of Sciences…
- 22 June 1999
It is concluded that the cloned cDNAs encode cholesterol 24-hydroxylases that synthesize oxysterols in neurons of the brain and that secretion of 24S-hydroxycholesterol from this tissue in the mouse is developmentally regulated.
The LDL receptor locus in familial hypercholesterolemia: mutational analysis of a membrane protein.
LMSD: LIPID MAPS structure database
The LIPID MAPS Structure Database (LMSD) is a relational database encompassing structures and annotations of biologically relevant lipids that provides the capability to perform a substructure search or exact match for the structure drawn by the user.
Steroid 5 alpha-reductase: two genes/two enzymes.
The structure of the determinants of apoptosis, a type of cell death, and the role that individual cells play in this process are studied.
Lipidomics reveals a remarkable diversity of lipids in human plasma1[S]
The focus of the present study was to define the human plasma lipidome and to establish novel analytical methodologies to quantify the large spectrum of plasma lipids and to quantitatively assessed the levels of over 500 distinct molecular species distributed among the main lipid categories.
The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development.
It is hypothesized that EPAS1 expressed in the OZ senses hypoxia during mid-gestational development and translates this signal into an altered pattern of gene expression, leading to increases in circulating catecholamine levels and proper cardiac function.