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We previously reported that in vivo cimetidine inhibits hepatic microsomal enzyme activities mediated by cytochrome P450 (CYP… Expand Piperine, a major active component of black and long peppers, has been reported to enhance drug bioavailability. The present… Expand Guinea pig adrenals possess a distinctive zona reticularis which increases in volume as the animal matures, coming to occupy over… Expand SummaryThe acute effects of the PCB (polychlorinated biphenyls) mixture (Aroclor 1254) on microsomal enzymes and on synthesis and… Expand The effects of clofibrate on the fine structure and drug-metabolizing capacity of livers of normolipidemic young adult virgin (YA… Expand Abstract The rate of reduction of cytochrome P450 in hepatic microsomes in the presence of NADPH has been measured with a dual… Expand Abstract The oxidative metabolism of piperonyl butoxide to a metabolite which forms a complex with reduced cytochrome P-450 is… Expand Abstract Cobalt chloride administration to rats stimulates erythropoesis but inhibits the synthesis of hepatic microsomal P-450… Expand Kinetic constants were determined for hepatic microsomal aniline hydroxylase and ethylmorphine N-demethylase in control female… Expand 1. Changes in certain kinetic properties (V(max.) and apparent K(m)) of hepatic microsomal mixed-function oxidases have been… Expand