Ethylmorphine-N-Demethylase

Known as: Ethylmorphine N Demethylase, Demethylase, Ethylmorphine N, N Demethylase, Ethylmorphine 
A drug-metabolizing enzyme of the hepatic microsomal oxidase system which catalyzes the oxidation of the N-methyl group of ethylmorphine with the… (More)
National Institutes of Health

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Papers overview

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2000
2000
Effect of vitamin E on lipid peroxidation and liver monooxigenase activity in experimental influenza virus infection.
Influenza virus infection was associated with development of oxidative stress in liver of mice, viz. increase in amount of lipid… (More)
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1998
1998
Ethylmorphine N-demethylase activity as a marker for cytochrome P450 CYP3A activity in rat hepatic microsomes.
The purpose of this study was to evaluate the selectivity and sensitivity of ethylmorphine N-demethylase (EMD) as an indicator of… (More)
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1990
1990
Sex differences in hepatic cytochrome P-450 monooxygenase activities in rainbow trout during an annual reproductive cycle.
Hepatic microsomal cytochrome P-450 monooxygenase activities were investigated in rainbow trout during an annual reproductive… (More)
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1989
1989
Decreased estrogen hydroxylation in male rat liver following cimetidine treatment.
Administration of cimetidine (600 mumol/kg x 5) to adult male rats resulted in 55 and 25% decreases, respectively, in estradiol 2… (More)
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1987
1987
Further studies on the persistence of neonatal androgen imprinting on sex-specific cytochrome P-450, testosterone and drug oxidations.
Neonatal castration completely suppressed the expression of P-450-male and expressed P-450-female; and testosterone treatment in… (More)
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Highly Cited
1985
Highly Cited
1985
Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism.
Piperine, a major active component of black and long peppers, has been reported to enhance drug bioavailability. The present… (More)
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1985
1985
Selective induction of coumarin 7-hydroxylase by pyrazole in D2 mice.
Pyrazole, was given to DBA/2N (D2), C57BL/6N (B6) and AKR/N mice to study its effects on hepatic drug metabolism. A decrease in… (More)
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1978
1978
A quantitative analysis of fine structure and drug metabolism in livers of clofibrate-treated young adult and retired breeder rats.
The effects of clofibrate on the fine structure and drug-metabolizing capacity of livers of normolipidemic young adult virgin (YA… (More)
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1977
1977
Cause of decrease of ethylmorphine N-demethylase activity of lipid peroxidation in microsomes from the rat, guinea pig and rabbit.
There were marked differences among animal species between NADPH-dependent and ascorbic acid-Fe++-dependent lipid peroxidation… (More)
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1969
1969
Changes in certain kinetic properties of hepatic microsomal aniline hydroxylase and ethylmorphine demethylase associated with postnatal development and maturation in male rats.
1. Changes in certain kinetic properties (V(max.) and apparent K(m)) of hepatic microsomal mixed-function oxidases have been… (More)
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