• Publications
  • Influence
Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite.
TLDR
A dose threshold exists for bromobenzene-induced hepatic necrosis and it is demonstrated that the hepatotoxic metabolite is preferentially conjugated (detoxified) with glutathione, thereby depleting glutATHione from the liver. Expand
Acetaminophen-induced hepatic necrosis. IV. Protective role of glutathione.
TLDR
A fundamental role of glutathione in the body may be to protect tissues against electrophilic attack by drug metabolites and other alkylating agents. Expand
Acetaminophen-induced hepatotoxicity.
TLDR
Changes in protein covalent binding caused by various treatments correlates with changes in the incidence and severity of the hepatic necrosis. Expand
Acetaminophen-induced hepatic necrosis. I. Role of drug metabolism.
TLDR
It is proposed thatacetaminophen-induced hepatic necrosis is mediated by a toxic metabolite of acetaminophen, which inhibits synthesis of cytochrome P-450 and thereby prevented the hepatic damage. Expand
Acetaminophen-induced hepatic necrosis. II. Role of covalent binding in vivo.
TLDR
It is proposed that acetaminophen-induced hepatic necrosis may be caused by the covalent binding of a chemically reactive metabolite to vital hepatsic macromolecules. Expand
FACTORS AFFECTING DRUG METABOLISM
  • J. Gillette
  • Medicine
  • Annals of the New York Academy of Sciences
  • 1 July 1971
TLDR
It has become increasingly evident that most of the oxidative reactions are catalyzed by enzyme systems in liver endoplasmic reticulum, which is disrupted by homogenization to form microsomes, and the diversity of the reactions catalyzing by these enzymes is virtually unique in biochemistry. Expand
Debrisoquine 4-hydroxylase: characterization of a new P450 gene subfamily, regulation, chromosomal mapping, and molecular analysis of the DA rat polymorphism.
TLDR
It is demonstrated that debrisoquine 4-hydroxylase is a member of a new constitutively expressed P450II sub-family containing two or more genes in the rat and established that thebrisoquine polymorphism in the DA rat is probably due to a structurally altered db1 protein. Expand
3-Hydroxyacetaminophen: a microsomal metabolite of acetaminophen. Evidence against an epoxide as the reactive metabolite of acetaminophen.
3-Hydroxyacetaminophen has been isolated and identified as a microsomal metabolite of acetaminophen. Analysis of the metabolite by gas chromatography-mass spectrometry revealed that the metaboliteExpand
Theoretic aspects of pharmacokinetic drug interactions
  • J. Gillette, K. Pang
  • Chemistry, Medicine
  • Clinical pharmacology and therapeutics
  • 1 November 1977
TLDR
In order to illustrate the effects of alterations in blood flow rates, enzyme activity, and reversible binding to blood components on the total body clearance of drugs, mathematical equations were derived for a general pharmacokinetic model that includes elimination of drugs by feces, intestinal mucosa, liver (metabolism and biliary excretion), lung, and kidney. Expand
SPECIES DIFFERENCES IN THE METABOLISM OF IMIPRAMINE AND DESMETHYLIMIPRAMINE (DMI).
TLDR
Evidence presented in this paper indicates that differences in the metabolism of imipramine and DMI may partially explain the species variations in the pharmacologic response of these "antisedative" compounds. Expand
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