• Publications
  • Influence
Cardiovascular effects of the macrolide antibiotic tilmicosin, administered alone and in combination with propranolol or dobutamine, in conscious unrestrained dogs.
TLDR
The data indicate that toxic doses of TM may have a negative inotropic effect in conscious dogs and that treatment with propranolol or dobutamine HCl reversed some, but not all, of the effects caused by TM administration. Expand
Cadmium-induced alteration of the microsomal mono-oxygenase system in male rat liver: Effects on hemoprotein turnover and phospholipid content☆
Abstract After cadmium treatment (2.0 mg Cd/kg, i.p.) a marked inhibition is observed in microsomal drug metabolizing enzyme activity which is correlated with a reduction in the hemoprotein,Expand
Toxicological evaluation of the cardiotonic isomazole in the dog.
TLDR
Results of these studies demonstrated that repeated IMZ administration, as expected, was cardiotoxic to the dog, a species relatively sensitive to the pharmacological activity and hemodynamic changes induced by vasodilator/cardiotonic drugs. Expand
Studies on the mechanism of cadmium-induced inhibition of the hepatic microsomal monooxygenase of the male rat.
TLDR
In vitro addition of Cd2+ to liver microsomes produced a concentration-dependent inhibition of the metabolism of the substrates tested, a reduction in thelevel of cytochrome P-450 which was accompanied by an increase in the level of the inactive form of the hemo-protein, P-420, and decreases in the microsomal binding spectra of the three substrates. Expand
Studies on cadmium-induced inhibition of hepatic microsomal drug biotransformation in the rat.
TLDR
Characterization of the tolerance phenomenon in terms of onset, duration, and intensity reveals a good correlation with the kinetics of metallothionein production, suggesting that the underlying basis for theolerance phenomenon is likely the induction of metalothione in rats. Expand
Protection by zinc against acetaminophen induced hepatotoxicity in mice.
TLDR
The results indicate that zinc protects against acetaminophen induced hepatotoxicity and that the observed protection is probably due to an induced biochemical change, but it is apparently not the result of any of the commonly invoked mechanisms. Expand
Acute and subchronic toxicology of LY-195115 in rats and dogs.
TLDR
Subchronic exposure of rats to doses of LY-195115 as high as 70mg/kg produced minimal mortality, renal toxicity, and mild, limited vascular changes, while dogs tolerated doses up to 0.5 mg/kg with no evidence of any effect of treatment except minimal histological changes in the heart consequent to the expected cardiotonic action of the compound. Expand
Acute, subchronic, and chronic toxicity of the cardiotonic isomazole in rats.
TLDR
Isomazole produced significant increases in hepatic p-nitroanisole O-demethylase activity and relative liver weight primarily at the 65 and 198 mg/kg treatment levels, consistent with induction of the hepatic drug-metabolizing enzyme system. Expand
Coronary Artery Toxicity in Beagle Dogs Given Indolidan, a Type III Phosphodiesterase Inhibitor
TLDR
Coronary Artery Toxicity in Beagle Dogs Given Indolidan, a Type III Phosphodiesterase Inhibitor is evaluated, characterized by marked smooth muscle necrosis involving most of the media, destruction of the internal elastic membrane, and marked adventitial fibroplasia. Expand
Comparative Cardiovascular Toxicity in Dogs Given Inotropic Agents by Continuous Intravenous Infusion
TLDR
The results indicated that NE and DP produced the most severe cardiovascular lesions, followed by IP which produced lesions of more moderate severity, and DB produced only slight lesions in comparison to the other 3 inotropic amines. Expand
...
1
2
...