Epithelial ovarian cancer
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Recent morphologic, immunohistochemical, and molecular genetic studies have led to the development of a new paradigm for the… Expand Ovarian cancer is the most lethal gynecologic malignancy. Efforts at early detection and new therapeutic approaches to reduce… Expand Epithelial ovarian cancer (EOC) is the sixth most common cancer in women worldwide and, despite advances in detection and… Expand In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203-213], the presence of CD3+ tumor-infiltrating lymphocytes… Expand Regulatory T (Treg) cells mediate homeostatic peripheral tolerance by suppressing autoreactive T cells. Failure of host antitumor… Expand BACKGROUND
Although tumor-infiltrating T cells have been documented in ovarian carcinoma, a clear association with clinical… Expand Germline mutations in BRCA1 and BRCA2 confer high risks of breast and ovarian cancer, but the average magnitude of these risks is… Expand Data collected from 2,197 white ovarian cancer patients and 8,893 white controls in 12 US case-control studies conducted in the… Expand Previous studies have suggested that overexpression of HER-2/neu oncogene occurs in 15-40% of breast cancers and that… Expand The murine monoclonal antibody OC 125 reacts with an antigen (CA 125) common to most nonmucinous epithelial ovarian carcinomas… Expand