Eotaxin

Known as: Chemokine, CCL11, CCL11 Chemokine, Chemokine CCL11 
A CC-type chemokine that is specific for CCR3 RECEPTORS. It is a potent chemoattractant for EOSINOPHILS.
National Institutes of Health

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CC chemokine ligand 11, N-nonanoyl(1)-CCL11 protein, human
CCL11 geneEotaxin-1 MeasurementIn BloodProcess of secretion
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Papers overview

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Highly Cited
2001
Highly Cited
2001
A pathological function for eotaxin and eosinophils in eosinophilic gastrointestinal inflammation
Although eosinophils have been implicated in the pathogenesis of gastrointestinal disorders, their function has not been… (More)
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Highly Cited
2000
Highly Cited
2000
Cc Chemokine Receptor (Ccr)3/Eotaxin Is Followed by Ccr4/Monocyte-Derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge in Vivo
Isolated peripheral blood CD4 cells from allergic individuals express CC chemokine receptor (CCR)3 and CCR4 after expansion in… (More)
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Highly Cited
1999
Highly Cited
1999
Eosinophil chemotactic chemokines (eotaxin, eotaxin-2, RANTES, monocyte chemoattractant protein-3 (MCP-3), and MCP-4), and C-C chemokine receptor 3 expression in bronchial biopsies from atopic and…
Atopic (AA) and nonatopic (NAA) asthma are characterized by chronic inflammation and local tissue eosinophilia. Many C-C… (More)
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Highly Cited
1998
Highly Cited
1998
Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes
Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better… (More)
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Highly Cited
1997
Highly Cited
1997
Targeted Disruption of the Chemokine Eotaxin Partially Reduces Antigen-induced Tissue Eosinophilia
The chemokines are a large group of chemotactic cytokines that regulate leukocyte trafficking and have recently been shown to… (More)
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Highly Cited
1997
Highly Cited
1997
High expression of the chemokine receptor CCR3 in human blood basophils. Role in activation by eotaxin, MCP-4, and other chemokines.
Eosinophil leukocytes express high numbers of the chemokine receptor CCR3 which binds eotaxin, monocyte chemotactic protein (MCP… (More)
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Highly Cited
1997
Highly Cited
1997
Eotaxin-2, a Novel CC Chemokine that Is Selective for the Chemokine Receptor CCR3, and Acts Like Eotaxin on Human Eosinophil and Basophil Leukocytes
A novel human CC chemokine consisting of 78 amino acids and having a molecular mass of 8,778.3 daltons (VVIPSPCCMF FVSKRIPENR… (More)
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Highly Cited
1996
Highly Cited
1996
Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils.
The CC chemokine eotaxin, identified in guinea pigs and also recently in mice, may be a key element for the selective recruitment… (More)
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Highly Cited
1995
Highly Cited
1995
Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo
Experiments were designed to study the effect of systemically administered IL-5 on local eosinophil accumulation induced by the… (More)
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Highly Cited
1994
Highly Cited
1994
Eotaxin: a potent eosinophil chemoattractant cytokine detected in a guinea pig model of allergic airways inflammation
Eosinophil accumulation is a prominent feature of allergic inflammatory reactions, such as those occurring in the lung of the… (More)
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