The immune geography of IgA induction and function
- A. Macpherson, K. McCoy, F. Johansen, P. Brandtzaeg
- Biology, MedicineMucosal Immunology
The mechanisms underlying selective IgA induction of mucosal B cells for IgA production and the immune geography of their homing characteristics are discussed, and the functionality of secretory IgA directed against both commensal organisms and pathogens is reviewed.
Gluten induces an intestinal cytokine response strongly dominated by interferon gamma in patients with celiac disease.
- E. Nilsen, F. Jahnsen, P. Brandtzaeg
- Medicine, BiologyGastroenterology
- 1 September 1998
Depletion of Murine Intestinal Microbiota: Effects on Gut Mucosa and Epithelial Gene Expression
- D. Reikvam, A. Erofeev, F. Johansen
- BiologyPLoS ONE
- 21 March 2011
A robust protocol for depleting conventionally raised mice of their cultivatable intestinal microbiota with antibiotics by gavage is presented and it is shown that the biological effect of this depletion phenocopies physiological characteristics of germ-free mice.
Interaction of ATF6 and serum response factor
- C. Zhu, F. Johansen, R. Prywes
- Biology, ChemistryMolecular and Cellular Biology
- 1 September 1997
A yeast interaction assay was used to screen a human HeLa cell cDNA library for SRF-interacting proteins and found an antisense ATF6 construct reduced serum induction of a c-fos reporter gene, suggesting that ATF6 is involved in activation of transcription by SRF.
Molecular characterization of NF-HEV, a nuclear factor preferentially expressed in human high endothelial venules.
- E. S. Baekkevold, M. Roussigné, J. Girard
- BiologyAmerican Journal of Pathology
- 1 July 2003
The B‐cell system of human mucosae and exocrine glands
- P. Brandtzaeg, I. Farstad, F. Johansen, H. Morton, I. Norderhaug, T. Yamanaka
- BiologyImmunological Reviews
- 1 October 1999
The mucosae and exocrine glands harbour the largest activated B‐cell system of the body, amounting to some 80–90% of all immunoglobulins (Ig)‐producing cells, and the origin of regionalized homing of B cells to secretory effector sites outside the gut remains elusive.
Absence of Epithelial Immunoglobulin a Transport, with Increased Mucosal Leakiness, in Polymeric Immunoglobulin Receptor/Secretory Component–Deficient Mice
- F. Johansen, M. Pekna, P. Brandtzaeg
- Biology, MedicineJournal of Experimental Medicine
- 4 October 1999
Complete lack of active external IgA and IgM translocation in pIgR knockout mice is reported, indicating no redundancy in epithelial transport mechanisms and production of SIgA might be a variable in the initiation of human immunopathology such as inflammatory bowel disease or gluten-sensitive enteropathy.
Mucosal B cells: phenotypic characteristics, transcriptional regulation, and homing properties
- P. Brandtzaeg, F. Johansen
- BiologyImmunological Reviews
- 1 August 2005
Data suggest a remarkable compartmentalization of the mucosal immune system that must be taken into account in the development of effective local vaccines to protect specifically the airways, eyes, oral cavity, small and large intestines, and urogenital tract.
RhoA Signaling via Serum Response Factor Plays an Obligatory Role in Myogenic Differentiation*
- Lei Wei, Wei Zhou, R. Schwartz
- BiologyJournal of Biological Chemistry
- 13 November 1998
This study supports the concept that RhoA signaling via SRF serves as an obligatory muscle differentiation regulatory pathway.
Two pathways for serum regulation of the c-fos serum response element require specific sequence elements and a minimal domain of serum response factor
- F. Johansen, R. Prywes
- BiologyMolecular and Cellular Biology
- 1 September 1994
A pathway for serum induction is found that is sensitive to mutations in the A/T-containing central sequence of the SRE and which is independent of TCF, demonstrating that TCF can also function in serum induction.