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Mast-cell infiltration of airway smooth muscle in asthma.
BACKGROUND Asthma and eosinophilic bronchitis are characterized by similar inflammatory infiltrates in the submucosa of the lower airway. However, eosinophilic bronchitis differs from asthma in thatExpand
Asthma exacerbations and sputum eosinophil counts: a randomised controlled trial
BACKGROUND Treatment decisions in asthma are based on assessments of symptoms and simple measures of lung function, which do not relate closely to underlying eosinophilic airway inflammation. WeExpand
Mepolizumab and exacerbations of refractory eosinophilic asthma.
BACKGROUND Exacerbations of asthma are associated with substantial morbidity and mortality and with considerable use of health care resources. Preventing exacerbations remains an important goal ofExpand
Evidence of a role of tumor necrosis factor alpha in refractory asthma.
BACKGROUND The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma. METHODS We measured markers ofExpand
The role of the mast cell in the pathophysiology of asthma.
There is compelling evidence that human mast cells contribute to the pathophysiology of asthma. Mast cells, but not T cells or eosinophils, localize within the bronchial smooth muscle bundles inExpand
The CXCL10/CXCR3 axis mediates human lung mast cell migration to asthmatic airway smooth muscle.
Mast cell microlocalization within the airway smooth muscle bundle is an important determinant of the asthmatic phenotype. We hypothesized that mast cells migrate toward airway smooth muscle inExpand
Macrophages within NSCLC tumour islets are predominantly of a cytotoxic M1 phenotype associated with extended survival
There is a marked survival advantage for patients with nonsmall cell lung cancer (NSCLC) expressing high numbers of macrophages in their tumour islets. The primary aim of the present study was toExpand
Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.
Asthma is characterized by the presence of an inflammatory cell infiltrate in the bronchial mucosa consisting of activated mast cells, eosinophils, and T cells. Several cytokines are considered toExpand
Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
BACKGROUND Eosinophilic airway inflammation is heterogeneous in asthmatic patients. We recently described a distinct subtype of asthma defined by the expression of genes inducible by T(H)2 cytokinesExpand
Increased sputum and bronchial biopsy IL-13 expression in severe asthma.
BACKGROUND The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 inExpand