Endothelin-1 Receptor, Human

Known as: Endothelin A Receptor, ETA-R, ET-A 
Endothelin-1 receptor (427 aa, ~49 kDa) is encoded by the human EDNRA gene. This protein is a multipass transmembrane protein that is a receptor for… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2017
0102019892017

Related topics

Related topics

13 relations
EDNRA geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingIntegral Membrane Proteins
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Broader (1)

Receptor, Endothelin A

Related mentions per year

Related mentions per year

1936-2019
19401960198020002020
Endothelin-1 Receptor, Human
Plasma membrane
Signal Transduction
Integral Membrane Proteins
Transmembrane Domain
Ligand Binding

Papers overview

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Highly Cited
2009
Highly Cited
2009
Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea.
OBJECTIVES Our aim was to investigate the involvement of the endothelin (ET) system in the cardiovascular consequences of… (More)
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2009
2009
Contribution of endothelin A receptors in endothelin 1-dependent natriuresis in female rats.
Renal medullary endothelin B receptors contribute to blood pressure regulation by facilitating salt excretion. Premenopausal… (More)
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2008
2008
Effects of nonselective endothelin-1 receptor antagonism on cardiac mast cell-mediated ventricular remodeling in rats.
The objective of this study was to investigate the effect a nonselective endothelin-1 (ET-1) receptor antagonist (bosentan) had… (More)
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2006
2006
Leptin regulates cardiomyocyte contractile function through endothelin-1 receptor-NADPH oxidase pathway.
Leptin, the obese gene product, plays an important role in the regulation of cardiac function. However, the mechanism behind… (More)
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2004
2004
Inhibition of cyclooxygenase-1 and -2 expression by targeting the endothelin a receptor in human ovarian carcinoma cells.
PURPOSE AND EXPERIMENTAL DESIGN New therapies against cancer are based on targeting cyclooxygenase (COX)-2. Activation of the… (More)
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2001
2001
Endothelin-1, endothelin-1 receptors and cardiac natriuretic peptides in failing human heart.
Endothelin (ET)-1 is a potent vasoconstrictor peptide produced in the myocardium that can exert important effects on cardiac… (More)
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Highly Cited
1997
Highly Cited
1997
The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats.
Exposure to hypoxia is associated with increased pulmonary artery pressure and plasma endothelin (ET-1) levels and with selective… (More)
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1994
1994
Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation.
To determine the potential contribution of endothelin (ET) to modulation of high pulmonary vascular resistance in the normal… (More)
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1993
1993
The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion.
OBJECTIVE The aim was to determine the effect of the endothelin-1 receptor antagonist, BQ-123, on infarct size in anaesthetised… (More)
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1991
1991
Cloning and expression of human endothelin-1 receptor cDNA.
We isolated a human endothelin-1 (ET-1) receptor cDNA from a human placenta cDNA library. The cDNA encodes a 427-amino acid… (More)
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