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Endothelin-1 Receptor, Human

Known as: Endothelin A Receptor, ETA-R, ET-A 
Endothelin-1 receptor (427 aa, ~49 kDa) is encoded by the human EDNRA gene. This protein is a multipass transmembrane protein that is a receptor for… Expand
National Institutes of Health

Related topics

Related topics

13 relations
EDNRA geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingIntegral Membrane Proteins
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Broader (1)

Receptor, Endothelin A

Papers overview

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Highly Cited
2009
Highly Cited
2009
Major role for hypoxia inducible factor-1 and the endothelin system in promoting myocardial infarction and hypertension in an animal model of obstructive sleep apnea.
OBJECTIVES Our aim was to investigate the involvement of the endothelin (ET) system in the cardiovascular consequences of… Expand
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Highly Cited
2009
Highly Cited
2009
Contribution of Endothelin A Receptors in Endothelin 1–Dependent Natriuresis in Female Rats
Renal medullary endothelin B receptors contribute to blood pressure regulation by facilitating salt excretion. Premenopausal… Expand
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Highly Cited
2006
Highly Cited
2006
Leptin Regulates Cardiomyocyte Contractile Function Through Endothelin-1 Receptor–NADPH Oxidase Pathway
Leptin, the obese gene product, plays an important role in the regulation of cardiac function. However, the mechanism behind… Expand
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Highly Cited
2004
Highly Cited
2004
Inhibition of Cyclooxygenase-1 and -2 Expression by Targeting the Endothelin A Receptor in Human Ovarian Carcinoma Cells
Purpose and Experimental Design: New therapies against cancer are based on targeting cyclooxygenase (COX)-2. Activation of the… Expand
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Review
2001
Review
2001
The role of endothelins and their receptors in heart failure.
Endothelin (ET) is a peptide composed of 21 amino acids, derived from a larger precursor, the big-endothelin, by action of the… Expand
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1999
1999
Characterization of endothelin-1 receptor subtypes in isolated human cardiomyocytes.
On cardiac membranes and isolated cardiomyocytes from the human heart, cell-type distribution and functional activities of… Expand
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Highly Cited
1997
Highly Cited
1997
The orally active nonpeptide endothelin A-receptor antagonist A-127722 prevents and reverses hypoxia-induced pulmonary hypertension and pulmonary vascular remodeling in Sprague-Dawley rats.
Exposure to hypoxia is associated with increased pulmonary artery pressure and plasma endothelin (ET-1) levels and with selective… Expand
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Highly Cited
1994
Highly Cited
1994
Physiologic characterization of endothelin A and B receptor activity in the ovine fetal pulmonary circulation.
To determine the potential contribution of endothelin (ET) to modulation of high pulmonary vascular resistance in the normal… Expand
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Highly Cited
1993
Highly Cited
1993
The endothelin-1 receptor antagonist BQ-123 reduces infarct size in a canine model of coronary occlusion and reperfusion.
OBJECTIVE The aim was to determine the effect of the endothelin-1 receptor antagonist, BQ-123, on infarct size in anaesthetised… Expand
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Highly Cited
1991
Highly Cited
1991
Cloning and expression of human endothelin-1 receptor cDNA.
We isolated a human endothelin-1 (ET-1) receptor cDNA from a human placenta cDNA library. The cDNA encodes a 427-amino acid… Expand
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