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Endothelin-1 Receptor, Human

Known as: Endothelin A Receptor, ETA-R, ET-A 
Endothelin-1 receptor (427 aa, ~49 kDa) is encoded by the human EDNRA gene. This protein is a multipass transmembrane protein that is a receptor for… 
National Institutes of Health

Related topics

Related topics

13 relations
EDNRA geneG Protein-Coupled Receptor GenesG Protein-Coupled Receptor SignalingIntegral Membrane Proteins

Broader (1)

Receptor, Endothelin A

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
Differential modulation of the expression of important drug metabolising enzymes and transporters by endothelin-1 receptor antagonists ambrisentan and bosentan in vitro.
2010
2010
Abnormal protein expression in the corpus cavernosum impairs erectile function in type 2 diabetes
Study Type – Aetiology (case control)
Level of Evidence 3b 
2008
2008
Common genetic variation in the type A endothelin-1 receptor is associated with ambulatory blood pressure: a family study
The endothelins are among the most potent vasoconstrictors known. Pharmacological inhibition of endothelin receptors lowers blood… 
2005
2005
Effects of a dual endothelin-1 receptor antagonist on airway obstruction and acute lung injury in sheep following smoke inhalation and burn injury.
Studies have suggested that ET-1 (endothelin-1) is associated with lung injury, airway inflammation and increased vascular… 
Highly Cited
2002
Highly Cited
2002
A pivotal role for cADPR‐mediated Ca2+ signaling: regulation of endothelin‐induced contraction in peritubular smooth muscle cells
cADPR, a potent calcium‐mobilizing intracellular messenger synthesized by ADP‐ribosyl cyclases regulates openings of ryanodine… 
2001
2001
Intrathecal administration of endothelin-1 receptor antagonist ameliorates autoimmune encephalomyelitis in Lewis rats
The role of endothelin-1(ET-1) in the development of experimental autoimmune encephalomyelitis (EAE) was studied by the blocking… 
2000
2000
Endothelin and free radicals modulate microvascular responses in streptozotocin-induced diabetic rats.
The quantitative contribution of endothelin and free radicals in modulating peripheral endothelial and smooth muscle-dependent… 
1997
1997
Additional hypotensive effect of endothelin-1 receptor antagonism in hypertensive dogs under angiotensin-converting enzyme inhibition.
BACKGROUND Endothelin-1 (ET-1) may play a role in hypertension. ET-1 receptor antagonism by bosentan lowers blood pressure in… 
1995
1995
Effects of endothelin-1 and endothelin-A receptor antagonist on recovery after hypothermic cardioplegic ischemia in neonatal lamb hearts.
BACKGROUND Prior studies suggest an important role for coronary endothelium in ischemia/reperfusion (I/R) injury. Decreased… 
1989
1989
Identification of the Endothelin‐1 Receptor in the Chick Heart
Summary This study suggests that binding sites for endothelin-1 (ET-1) are distinct from those for dihydropyridine (DHP… 
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