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EWSR1 gene

Known as: EWS, EWS GENE, EWING SARCOMA BREAKPOINT REGION 1 
This gene may play a role in post-transcriptional regulation; however the function remains to be elucidated. Mutations in the gene result in Ewing… 
National Institutes of Health

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Related topics

29 relations
Askin's tumorDesmoplastic Small Round Cell TumorETV4 geneEWSR1 protein, human

Papers overview

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Highly Cited
2014
Highly Cited
2014
Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis.
Chromosomal translocation that results in fusion of the genes encoding RNA-binding protein EWS and transcription factor FLI1 (EWS… 
Highly Cited
2004
Highly Cited
2004
Selective Usage of D-Type Cyclins by Ewing’s Tumors and Rhabdomyosarcomas
The genetic mechanisms that control proliferation of childhood musculoskeletal malignancies, notably Ewing’s tumor (ET) and… 
Highly Cited
2003
Highly Cited
2003
EWS/ETS fusions activate telomerase in Ewing's tumors.
EWS/ETS is a chimeric protein identified in most Ewing's sarcomas. Although EWS/ETS has been shown to activate transcription as a… 
Highly Cited
2003
Highly Cited
2003
PIM3 Proto-Oncogene Kinase Is a Common Transcriptional Target of Divergent EWS/ETS Oncoproteins
ABSTRACT Despite significant structural diversity, present evidence suggests that EWS/ETS fusion proteins promote oncogenesis by… 
Highly Cited
2001
Highly Cited
2001
Exposure on Cell Surface and Extensive Arginine Methylation of Ewing Sarcoma (EWS) Protein*
In contrast to the knowledge regarding the function of chimeric Ewing sarcoma (EWS) fusion proteins that arise from chromosomal… 
Highly Cited
1999
Highly Cited
1999
EWS-FLI1 and EWS-ERG gene fusions are associated with similar clinical phenotypes in Ewing's sarcoma.
PURPOSE There are a variety of solid tumors in which alternative chromosomal translocations generate related fusion products. In… 
Highly Cited
1999
Highly Cited
1999
Regulation of the human poly(ADP-ribose) polymerase promoter by the ETS transcription factor
Ewing's sarcoma (EWS) cells accumulate elevated steady-state levels of poly (ADP-ribose) polymerase (PARP) mRNA and protein. To… 
Highly Cited
1998
Highly Cited
1998
Oncogenic EWS-Fli1 interacts with hsRPB7, a subunit of human RNA polymerase II
As a result of the t(11;22)(q24;q12) chromosomal translocation characterizing the Ewing family of tumors (ET), the amino terminal… 
Highly Cited
1998
Highly Cited
1998
Peripheral primitive neuroectodermal tumor of the ovary confirmed by CD99 immunostaining, karyotypic analysis, and RT-PCR for EWS/FLI-1 chimeric mRNA.
We report a case of peripheral primitive neuroectodermal tumor (pPNET), which belongs to the PNET/Ewing's sarcoma family, arising… 
Highly Cited
1997
Highly Cited
1997
FLI1 and EWS-FLI1 function as ternary complex factors and ELK1 and SAP1a function as ternary and quaternary complex factors on the Egr1 promoter serum response elements
The ETS gene products are a family of transcriptional regulatory proteins that contain a highly conserved and structurally unique… 
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