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EWSR1 gene

Known as: EWS, EWS GENE, EWING SARCOMA BREAKPOINT REGION 1 
This gene may play a role in post-transcriptional regulation; however the function remains to be elucidated. Mutations in the gene result in Ewing… 
National Institutes of Health

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29 relations
Askin's tumorDesmoplastic Small Round Cell TumorETV4 geneEWSR1 protein, human

Papers overview

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Highly Cited
2007
Highly Cited
2007
EWSR1‐CREB1 is the predominant gene fusion in angiomatoid fibrous histiocytoma
The molecular hallmark of angiomatoid fibrous histiocytoma (AFH) is not well defined, with only six cases with specific gene… 
Highly Cited
2005
Highly Cited
2005
Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma.
The development of effective, systemic therapies for metastatic cancer is highly desired. We show here that the systemic delivery… 
Highly Cited
2004
Highly Cited
2004
EWS/FLI-1 Silencing and Gene Profiling of Ewing Cells Reveal Downstream Oncogenic Pathways and a Crucial Role for Repression of Insulin-Like Growth Factor Binding Protein 3
ABSTRACT Ewing tumors are characterized by abnormal transcription factors resulting from the oncogenic fusion of EWS with members… 
Review
2001
Review
2001
Biology of EWS/ETS fusions in Ewing's family tumors
Tumor-associated chromosomal translocations lead to the formation of chimeric fusions between the EWS gene and one of five… 
Highly Cited
1995
Highly Cited
1995
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.
Most Ewing's sarcomas or related primitive neuroectodermal tumors have the (11;22)(q24;q12) or less frequently the (21;22)(q22… 
Highly Cited
1994
Highly Cited
1994
Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor.
The desmoplastic small round cell tumor (DSRCT) is a recently recognized type of primitive sarcoma defined by a predilection for… 
Highly Cited
1993
Highly Cited
1993
Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.
The 11;22 chromosomal translocation specifically linked to Ewing sarcoma and primitive neuroectodermal tumor results in a… 
Highly Cited
1993
Highly Cited
1993
The Ewing's sarcoma EWS/FLI-1 fusion gene encodes a more potent transcriptional activator and is a more powerful transforming gene than FLI-1
EWS/FLI-1 is a chimeric protein formed by a tumor-specific 11;22 translocation found in both Ewing's sarcoma and primitive… 
Highly Cited
1993
Highly Cited
1993
EWS and ATF-1 gene fusion induced by t(12;22) translocation in malignant melanoma of soft parts
The genes involved in the t(12;22)(q13;q12) translocation found recurrently in malignant melanoma of soft parts have been… 
Highly Cited
1993
Highly Cited
1993
Combinatorial generation of variable fusion proteins in the Ewing family of tumours.
Balanced translocations involving band q12 of human chromosome 22 are the most frequent recurrent translocations observed in… 
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