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Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks
The ability of the trained ANN models to recognize SRBCTs is demonstrated, and the potential applications of these methods for tumor diagnosis and the identification of candidate targets for therapy are demonstrated.
The landscape of somatic copy-number alteration across human cancers
It is demonstrated that cancer cells containing amplifications surrounding the MCL1 and BCL2L1 anti-apoptotic genes depend on the expression of these genes for survival, and a large majority of SCNAs identified in individual cancer types are present in several cancer types.
NCCN Task Force report: update on the management of patients with gastrointestinal stromal tumors.
- G. Demetri, M. von Mehren, J. Wayne
- MedicineJournal of the National Comprehensive Cancer…
- 1 April 2010
The standard of care for managing patients with gastrointestinal stromal tumors (GISTs) rapidly changed after the introduction of effective molecularly targeted therapies involving tyrosine kinase…
Adjuvant imatinib mesylate after resection of localised, primary gastrointestinal stromal tumour: a randomised, double-blind, placebo-controlled trial
Clinicopathologic correlates of solitary fibrous tumors
To the authors's knowledge, there are no large series reporting both thoracic and extrathoracic SFTs nor are there any large series that analyze clinicopathologic correlates of tumor behavior.
Subtype-specific genomic alterations define new targets for soft tissue sarcoma therapy
An integrative analysis of DNA sequence, copy number and mRNA expression in 207 samples encompassing seven major subtypes of soft-tissue sarcomas yields a detailed map of molecular alterations across diverse sarcoma subtypes and suggests potential subtype-specific targets for therapy.
Primary and secondary kinase genotypes correlate with the biological and clinical activity of sunitinib in imatinib-resistant gastrointestinal stromal tumor.
- M. Heinrich, R. Maki, G. Demetri
- Medicine, BiologyJournal of clinical oncology : official journal…
- 20 November 2008
The clinical activity of sunitinib after imatinib failure is significantly influenced by both primary and secondary mutations in the predominant pathogenic kinases, which has implications for optimization of the treatment of patients with GIST.
Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing
These studies establish NAB2-STAT6 as the defining driver mutation of SFT and provide an example of how neoplasia can be initiated by converting a transcriptional repressor of mitogenic pathways into an transcriptional activator.
Histologic Subtype and Margin of Resection Predict Pattern of Recurrence and Survival for Retroperitoneal Liposarcoma
The histologic subtype and margin of resection are prognostic for survival in primary retroperitoneal liposarcoma and may be needed to achieve complete resection but has no measurable influence on disease specific survival.
Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor.
- J. Butrynski, D. D’Adamo, G. Shapiro
- Biology, MedicineThe New England journal of medicine
- 28 October 2010
A sustained partial response to the ALK inhibitor crizotinib (PF-02341066, Pfizer) is reported in a patient with ALK-translocated IMT, as compared with no observed activity in another patient without theALK translocation, which support the dependence of ALk-rearranged tumors on AlK-mediated signaling and suggest a therapeutic strategy for genomically identified patients with the aggressive form of this soft-tissue tumor.