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A Phase I trial of the farnesyl transferase inhibitor SCH66336: evidence for biological and clinical activity.
TLDR
This study establishes the dose for future testing on this schedule and provides the first evidence of successful inhibition of FT in the clinical setting and the first hint of clinical activity for this class of agents.
Gfi‐1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA‐sensitive mechanism
TLDR
It is demonstrated that Gfi‐1 interacts with ETO and related proteins both in vitro and in vivo and with histone deacetylase proteins in vivo, and it is suggested that GFi‐1 proteins repress transcription through recruitment of Histone de acetylase‐containing complexes.
Enzymic procedures for determining the average state of adenylylation of Escherichia coli glutamine synthetase.
TLDR
Six different enzymic procedures have been developed and can be used to measure the state of adenylylation of glutamine synthetase in crude extracts with an accuracy of ±7%.
A variant Ewing's sarcoma translocation (7;22) fuses the EWS gene to the ETS gene ETV1.
TLDR
A third Ewing's sarcoma translocation is identified, the t(7;22)(p22;q12), that fuses EWS to the human homologue of the murine ETS gene ER81, and this gene, designated ETV1 (for ETS Translocation Variant), is located on chromosome band 7p22.
Genistein inhibits NF-kappa B activation in prostate cancer cells.
TLDR
Genistein's ability to abrogate NF-kappa B activation by DNA-damaging agents strongly supports genistein’s role as a chemopreventive agent.
The t(12;21) translocation converts AML-1B from an activator to a repressor of transcription
TLDR
The t(12;21) fusion protein dominantly interferes with AML-1B-dependent transcription, suggesting that the inhibition of expression of AML -1 genes is critical for B-cell leukemogenesis.
The ETO (MTG8) gene family.
TLDR
The ETO gene family now includes three human members encoding proteins composed of four evolutionarily conserved domains termed nervy homology regions (NHR) 1-4 and suggests that ETO proteins function as transcriptional corepressors.
The MN1-TEL Fusion Protein, Encoded by the Translocation (12;22)(p13;q11) in Myeloid Leukemia, Is a Transcription Factor with Transforming Activity
TLDR
It is shown that MN1-TEL type I, unlike TEL and MN1, transforms NIH 3T3 cells, and it is demonstrated thatMN1 has transcription activity and that MN2-T EL acts as a chimeric transcription factor on the Moloney sarcoma virus long terminal repeat and a synthetic promoter containing TEL binding sites.
Genistein-induced upregulation of p21WAF1, downregulation of cyclin B, and induction of apoptosis in prostate cancer cells.
TLDR
Experimental evidence is provided for a novel effect of genistein on cell cycle gene regulation, resulting in the inhibition of cell growth and ultimate demise of tumor cells.
Dual control of myc expression through a single DNA binding site targeted by ets family proteins and E2F-1.
TLDR
E2F-1 and ets family members may independently regulate c-myc transcription through the same binding site at different times following growth factor stimulation, suggesting that ets proteins may regulating c- myc expression.
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