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EPZ-6438

Known as: E7438, EPZ6438 
National Institutes of Health

Related topics

Related topics

3 relations

Broader (3)

BenzamidesPyridonesTazemetostat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells
Abstract Regulation of target proteins by the ubiquitin-proteasome system (UPS) is common in a wide range of cellular events… 
2020
2020
EZH2 inhibitors restore epigenetically silenced CD58 expression in B-cell lymphomas.
Highly Cited
2017
Highly Cited
2017
Multiple Histone Lysine Methyltransferases Are Required for the Establishment and Maintenance of HIV-1 Latency
ABSTRACT We showed previously that the histone lysine methyltransferase (HKMT) H3K27me3 (EZH2) is the catalytic subunit of… 
Review
2017
Review
2017
Epigenetics of oropharyngeal squamous cell carcinoma: opportunities for novel chemotherapeutic targets
Epigenetic modifications are heritable changes in gene expression that do not directly alter DNA sequence. These modifications… 
2017
2017
Enhancer of zeste homologue 2 plays an important role in neuroblastoma cell survival independent of its histone methyltransferase activity.
Highly Cited
2017
Highly Cited
2017
Dual inhibition of DNMTs and EZH2 can overcome both intrinsic and acquired resistance of myeloma cells to IMiDs in a cereblon‐independent manner
Thalidomide and its derivatives, lenalidomide and pomalidomide (also known as IMiDs), have significantly changed the treatment… 
Highly Cited
2016
Highly Cited
2016
The Ezh2 polycomb group protein drives an aggressive phenotype in melanoma cancer stem cells and is a target of diet derived sulforaphane
Melanoma is a metastatic cancer associated with poor survival. Here, we study a subpopulation of melanoma cancer cells displaying… 
Highly Cited
2016
Highly Cited
2016
EZH2 promotes colorectal cancer stem-like cell expansion by activating p21cip1-Wnt/β-catenin signaling
Because colorectal cancer (CRC) stem-like cells (CCS-like cells) contribute to poor patient prognosis, these cells are a… 
2014
2014
6LBA Phase 1 first-in-human study of the enhancer of zeste-homolog 2 (EZH2) histone methyl transferase inhibitor E7438 as a single agent in patients with advanced solid tumors or B cell lymphoma
Highly Cited
2014
Highly Cited
2014
Synergistic Anti-Tumor Activity of EZH2 Inhibitors and Glucocorticoid Receptor Agonists in Models of Germinal Center Non-Hodgkin Lymphomas
Patients with non-Hodgkin lymphoma (NHL) are treated today with a cocktail of drugs referred to as CHOP (Cyclophosphamide… 
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