EIF2AK4 wt Allele

Known as: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4 wt Allele, GCN2, KIAA1338 
Human EIF2AK4 wild-type allele is located in the vicinity of 15q13.1 and is approximately 101 kb in length. This allele, which encodes eukaryotic… (More)
National Institutes of Health

Papers overview

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Highly Cited
2013
Highly Cited
2013
In response to different environmental stresses, eIF2α phosphorylation represses global translation coincident with preferential… (More)
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Highly Cited
2010
Highly Cited
2010
The transcription factor ATF4 regulates the expression of genes involved in amino acid metabolism, redox homeostasis and ER… (More)
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Highly Cited
2007
Highly Cited
2007
L-arginine (L-Arg) plays a central role in several biologic systems including the regulation of T-cell function. L-Arg depletion… (More)
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Highly Cited
2003
Highly Cited
2003
Yeast protein kinase GCN2 stimulates the translation of transcriptional activator GCN4 by phosphorylating eIF2alpha in response… (More)
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Highly Cited
2003
Highly Cited
2003
Nuclear factor kappaB (NF-kappaB) serves to coordinate the transcription of genes in response to diverse environmental stresses… (More)
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Highly Cited
2003
Highly Cited
2003
L-Arginine is the only endogenous nitrogen-containing substrate of NO synthase (NOS), and it thus governs the production of NO… (More)
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Highly Cited
2002
Highly Cited
2002
The eIF2alpha kinases are a family of evolutionarily conserved serine/threonine kinases that regulate stress-induced… (More)
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Highly Cited
2001
Highly Cited
2001
Phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eIF2alpha) on serine 51 integrates general… (More)
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Highly Cited
1998
Highly Cited
1998
In response to various environmental stresses, eukaryotic cells down-regulate protein synthesis by phosphorylation of the alpha… (More)
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Highly Cited
1995
Highly Cited
1995
Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-tRNA synthetases juxtaposed to the… (More)
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