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EIF2AK4 wt Allele

Known as: Eukaryotic Translation Initiation Factor 2 Alpha Kinase 4 wt Allele, GCN2, KIAA1338 
Human EIF2AK4 wild-type allele is located in the vicinity of 15q13.1 and is approximately 101 kb in length. This allele, which encodes eukaryotic… 
National Institutes of Health

Related topics

Related topics

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PhosphorylationSerine/Threonine PhosphorylationSignal TransductionStress Response Signaling

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Characterization of Arabidopsis thaliana GCN2 kinase roles in seed germination and plant development
Eukaryotic GCN2 (general control nonderepressible 2) is a serine/threonine protein kinase that plays an essential role in… 
2015
2015
IDO-GCN2 and autophagy in inflammation
Inflammation is a disruptive force in the tissue microenvironment driving extracellular matrix reorganization, production of… 
2012
2012
Nanosecond pulsed electric fields act as a novel cellular stress that induces translational suppression accompanied by eIF2α phosphorylation and 4E-BP1 dephosphorylation.
Highly Cited
2011
Highly Cited
2011
Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death
The eukaryotic cell responds to various forms of environmental stress by adjusting the rates of mRNA translation thus… 
2010
2010
High expression of IMPACT protein promotes resistance to indoleamine 2,3‐dioxygenase‐induced cell death
Indoleamine 2,3‐dioxygenase (IDO), a tryptophan degrading enzyme, is a potent immunomodulatory factor. IDO expression in… 
2008
2008
Specific Inhibition of the PKR-Mediated Antiviral Response by the Murine Cytomegalovirus Proteins m142 and m143
ABSTRACT Double-stranded RNA (dsRNA) produced during viral infection activates several cellular antiviral responses. Among the… 
2008
2008
Distribution of the protein IMPACT, an inhibitor of GCN2, in the mouse, rat, and marmoset brain
IMPACT is an inhibitor of GCN2, a kinase that phosphorylates the alpha subunit of the translation initiation factor 2 (eIF2… 
2008
2008
Novel Function of PERK as a Mediator of Force-induced Apoptosis*
Induction of apoptosis by tensile forces is an important determinant of connective tissue destruction in osteoarthritis and… 
1998
1998
Isolation of the gene encoding the Drosophila melanogaster homolog of the Saccharomyces cerevisiae GCN2 eIF-2alpha kinase.
Genomic and cDNA clones homologous to the yeast GCN2 eIF-2alpha kinase (yGCN2) were isolated from Drosophila melanogaster. The… 
Highly Cited
1988
Highly Cited
1988
Transcriptional-translational regulatory circuit in Saccharomyces cerevisiae which involves the GCN4 transcriptional activator and the GCN2 protein kinase
GCN4 protein mediates the transcriptional activation of amino acid biosynthetic genes in Saccharomyces cerevisiae by specifically… 
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