Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death

@article{Peidis2011DoxorubicinBT,
  title={Doxorubicin bypasses the cytoprotective effects of eIF2α phosphorylation and promotes PKR-mediated cell death},
  author={Philippos Peidis and Andreas I. Papadakis and Hala Muaddi and Sylvain Richard and Antonis E. Koromilas},
  journal={Cell Death and Differentiation},
  year={2011},
  volume={18},
  pages={145-154}
}
The eukaryotic cell responds to various forms of environmental stress by adjusting the rates of mRNA translation thus facilitating adaptation to the assaulting stress. One of the major pathways that control protein synthesis involves the phosphorylation of the α-subunit of eukaryotic initiation factor eIF2 at serine 51. Different forms of DNA damage were shown to induce eIF2α phosphorylation by using PERK, GCN2 or PKR. However, the specificity of the eIF2α kinases and the biological role of… CONTINUE READING
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