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EGR1 protein, human

Known as: Transcription Factor Zif268, AT225, Egr-1 protein, human 
Early growth response protein 1 (543 aa, ~58 kDa) is encoded by the human EGR1 gene. This protein is involved in the modulation of both mitogenesis… 
National Institutes of Health

Related topics

Related topics

13 relations
Androgen Receptor Regulation PathwayCYS2-HIS2 Zinc FingersCell NucleusDNA-Binding Proteins

Broader (1)

Early Growth Response Protein 1

Papers overview

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Highly Cited
2005
Highly Cited
2005
Cyclooxygenase Inhibitors Induce the Expression of the Tumor Suppressor Gene EGR-1, Which Results in the Up-Regulation of NAG-1, an Antitumorigenic Protein
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to have chemopreventive activity, but the mechanisms involved are… 
Highly Cited
2001
Highly Cited
2001
Specificity, diversity, and convergence in VEGF and TNF‐α signaling events leading to tissue factor up regulation via EGR‐1 in endothelial cells
Tissue factor (TF) has been shown to be up‐regulated in endothelial cells by the inflammatory cytokine tumor necrosis factor a… 
Highly Cited
1996
Highly Cited
1996
Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1 (*)
Tissue factor (TF) gene expression is rapidly induced in epithelial cells by phorbol 12-myristate 13-acetate and serum. We have… 
Highly Cited
1996
Highly Cited
1996
Transcription factor EGR-1 suppresses the growth and transformation of human HT-1080 fibrosarcoma cells by induction of transforming growth factor beta 1.
The early growth response 1 (EGR-1) gene product is a transcription factor with role in differentiation and growth. We have… 
Highly Cited
1995
Highly Cited
1995
Interplay of Sp1 and Egr-1 in the Proximal Platelet-derived Growth Factor A-Chain Promoter in Cultured Vascular Endothelial Cells (*)
The platelet-derived growth factor (PDGF) A-chain has been implicated in the initiation and progression of vascular occlusive… 
Highly Cited
1995
Highly Cited
1995
Sequence and structural requirements for high-affinity DNA binding by the WT1 gene product
The Wilms' tumor suppressor gene, WT1, encodes a zinc finger polypeptide which plays a key role regulating cell growth and… 
Highly Cited
1991
Highly Cited
1991
Transcriptional repression mediated by the WT1 Wilms tumor gene product.
The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger… 
Highly Cited
1991
Highly Cited
1991
Constitutive expression of zif268 in neocortex is regulated by synaptic activity.
Transcription factors are rapidly and transiently induced in brain by excitatory stimuli and may be important in coordinating… 
Highly Cited
1990
Highly Cited
1990
Alpha- and beta-adrenergic stimulation induces distinct patterns of immediate early gene expression in neonatal rat myocardial cells. fos/jun expression is associated with sarcomere assembly; Egr-1…
Highly Cited
1988
Highly Cited
1988
5' flanking sequence and genomic structure of Egr-1, a murine mitogen inducible zinc finger encoding gene.
Egr-1 is a murine zinc finger encoding cDNA whose expression is modulated by a variety of ligand-receptor interactions and is… 
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